Jacobs, L and Thijs, L and Jin, Y and Zannad, F and Mebazaa, A and Rouet, P and Pinet, F and Bauters, C and Pieske, B and Tomaschitz, A and Mamas, M and Diez, J and McDonald, K and Cleland, JG and Rocca, HP and Heymans, S and Latini, R and Masson, S and Sever, P and Delles, C and Pocock, S and Collier, T and Kuznetsova, T and Staessen, JA (2014) Heart 'omics' in AGEing (HOMAGE): design, research objectives and characteristics of the common database. Journal of Biomedical Reseach, 28 (5). 349 -359. ISSN 1674-8301

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Abstract

Heart failure is common in older people and its prevalence is increasing. The Heart 'omics' in AGEing (HOMAGE) project aims to provide a biomarker approach that will improve the early diagnosis of heart failure. A large clinical database, based on (1) prospective population studies or (2) cross-sectional, prospective studies or randomized controlled trials (RCTs) of patients at risk for or with overt cardiovascular disease will be constructed to determine most promising 'omics'-based biomarkers to identify the risk of developing heart failure and/or comorbidities. Population studies, patient cohorts and RCTs are eligible for inclusion in the common database, if they received ethical approval to obtain and share data and have baseline information on cardiovascular risk factors. Currently, the HOMAGE database includes 43,065 subjects, from 20 studies in eight European countries, including healthy subjects from three population studies in France, Belgium and Italy (n  =  7,124), patients with heart failure (n  =  4,312) from four cohorts in the UK, Spain and Switzerland and patients at high risk for cardiovascular disease (n  =  31,629) in 13 cohorts. It is anticipated that more partners will join the consortium and enlarge the pooled data. This large merged database will be a useful resource with which to identify candidate biomarkers that play a role in the mechanism underlying the onset and progression of heart failure.

Item Type: Article
Uncontrolled Keywords: left ventricle, heart failure, heart failure with reduced ejection fraction, heart failure with preserved ejection fraction, population science, morbidity, mortality
Subjects: R Medicine > R Medicine (General)
Related URLs:
Depositing User: Symplectic
Date Deposited: 18 Aug 2015 12:52
Last Modified: 18 Aug 2015 13:04
URI: http://eprints.keele.ac.uk/id/eprint/575

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