Luscombe, CJ, French, ME, Liu, S, Saxby, MF, Jones, PW, Fryer, AA and Strange, RC (2001) Prostate cancer risk: associations with ultraviolet radiation, tyrosinase and melanocortin-1 receptor genotypes. British Journal of Cancer, 85 (10). 1504 - 1509. ISSN 1532-1827

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Abstract

Exposure to ultraviolet radiation may reduce prostate cancer risk, suggesting that polymorphism in genes that mediate host pigmentation will be associated with susceptibility to this cancer. We studied 210 prostate cancer cases and 155 controls to determine whether vitamin D receptor (VDR, Taql and Fokl variants), tyrosinase (TYR, codon 192 variant) and melanocortin-1 receptor (MC1R, Arg151Cys, Arg160Trp, Val92Met, Asp294His and Asp84Glu variants) genotypes are associated with risk. UV exposure was determined using a questionnaire. MC1R Arg(160)/Arg(160) homozygotes were at increased risk (P = 0.027, odds ratio = 1.94) while TYR A2/A2 homozygotes were at reduced risk of prostate cancer (P = 0.033, odds ratio = 0.48). These associations remained significant after correction for UV-exposure. Stratification of cases and controls by quartiles of exposure, showed that the protective effect of TYR A1A2 (P = 0.006, odds ratio 0.075) and A2A2 (P = 0.003, odds ratio 0.055) was particularly strong in subjects who had received the greatest exposure. Our data show for the first time, that allelism in genes linked with skin pigment synthesis is associated with prostate cancer risk possibly because it mediates the protective effects of UV. Importantly, susceptibility is associated with an interaction between host predisposition and exposure.

Item Type: Article
Additional Information: This is the final published version of the article (version of record). It first appeared online via Springer Nature at http://doi.org/10.1054/bjoc.2001.2097 - please refer to any applicable terms of use of the publisher.
Uncontrolled Keywords: Adult, Aged, Case-Control Studies, Environmental Exposure, Gene Frequency, Genetic Predisposition to Disease, Genotype, Humans, Logistic Models, Male, Middle Aged, Monophenol Monooxygenase, Prostatic Hyperplasia, Prostatic Neoplasms, Receptors, Calcitriol, Receptors, Corticotropin, Receptors, Melanocortin, Risk Factors, Ultraviolet Rays
Subjects: R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Divisions: Faculty of Medicine and Health Sciences > Institute for Science and Technology in Medicine
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Depositing User: Symplectic
Date Deposited: 12 Feb 2019 14:53
Last Modified: 12 Feb 2019 14:59
URI: http://eprints.keele.ac.uk/id/eprint/5825

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