Fath-Ordoubadi, F and Spaepen, E and El-Omar, M and Fraser, DG and Khan, MA and Neyses, L and Danzi, GB and Roguin, A and Paunovic, D and Mamas, MA (2014) Outcomes in patients with acute and stable coronary syndromes: insights from the prospective NOBORI-2 study. PLoS One, 9 (2). e88577 -?. ISSN 1932-6203
Outcomes in patients with acute and stable coronary syndromes; insights from the prospective NOBORI-2 study..pdf - Published Version
Available under License Creative Commons Attribution.
Download (569kB) | Preview
BACKGROUND: Contemporary data remains limited regarding mortality and major adverse cardiac events (MACE) outcomes in patients undergoing PCI for different manifestations of coronary artery disease. OBJECTIVES: We evaluated mortality and MACE outcomes in patients treated with PCI for STEMI (ST-elevation myocardial infarction), NSTEMI (non ST-elevation myocardial infarction) and stable angina through analysis of data derived from the Nobori-2 study. METHODS: Clinical endpoints were cardiac mortality and MACE (a composite of cardiac death, myocardial infarction and target vessel revascularization). RESULTS: 1909 patients who underwent PCI were studied; 1332 with stable angina, 248 with STEMI and 329 with NSTEMI. Age-adjusted Charlson co-morbidity index was greatest in the NSTEMI cohort (3.78±1.91) and lowest in the stable angina cohort (3.00±1.69); P<0.0001. Following Cox multivariate analysis cardiac mortality was independently worse in the NSTEMI vs the stable angina cohort (HR 2.31 (1.10-4.87), p = 0.028) but not significantly different for STEMI vs stable angina cohort (HR 0.72 (0.16-3.19), p = 0.67). Similar observations were recorded for MACE (<180 days) (NSTEMI vs stable angina: HR 2.34 (1.21-4.55), p = 0.012; STEMI vs stable angina: HR 2.19 (0.97-4.98), p = 0.061. CONCLUSIONS: The longer-term Cardiac mortality and MACE were significantly worse for patients following PCI for NSTEMI even after adjustment of clinical demographics and Charlson co-morbidity index whilst the longer-term prognosis of patients following PCI STEMI was favorable, with similar outcomes as those patients with stable angina following PCI.
|Uncontrolled Keywords:||coronary artery disease, major adverse cardiac events, MACE, acute coronary syndrome, demography, drug-eluting stents, Kaplan-Meier estimate, percutaneous coronary intervention, proportional hazards models|
|Subjects:||R Medicine > R Medicine (General)|
|Divisions:||Faculty of Medicine and Health Sciences > Institute for Science and Technology in Medicine|
|Date Deposited:||04 Jun 2015 15:04|
|Last Modified:||30 Nov 2016 14:35|
Actions (login required)