Binsaleh, NK, Wigley, CA, Whitehead, KA, van Rensburg, M, Reynisson, J ORCID: https://orcid.org/0000-0003-4174-9512, Pilkington, LI, Barker, D, Jones, S and Dempsey-Hibbert, NC (2018) Thieno[2,3-b]pyridine derivatives are potent anti-platelet drugs, inhibiting platelet activation, aggregation and showing synergy with aspirin. European Journal of Medicinal Chemistry, 143. 1997 - 2004.

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Abstract

Drugs which inhibit platelet function are commonly used to prevent blood clot formation in patients with Acute Coronary Syndromes (ACS) or those at risk of stroke. The thieno[3,2-c]pyridine class of therapeutic agents, of which clopidogrel is the most commonly used, target the P2Y12 receptor, and are often used in combination with acetylsalicylic acid (ASA). Six thieno[2,3-b]pyridine were assessed for in vitro anti-platelet activity; all derivatives showed effects on both platelet activation and aggregation, and showed synergy with ASA. Some compounds demonstrated greater activity when compared to clopidogrel. These compounds, therefore, represent potential novel P2Y12 inhibitors for improved treatment for patients.

Item Type: Article
Additional Information: The final version of this document is available online at https://www.sciencedirect.com/science/article/pii/S0223523417309078?via%3Dihub
Uncontrolled Keywords: Thienopyridine; Platelets; Thrombosis; Clopidogrel; Aspirin
Subjects: Q Science > QD Chemistry
Divisions: Faculty of Natural Sciences > School of Chemical and Physical Sciences
Related URLs:
Depositing User: Symplectic
Date Deposited: 28 Feb 2019 10:07
Last Modified: 28 Feb 2019 10:07
URI: http://eprints.keele.ac.uk/id/eprint/5939

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