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Early Clinical Outcomes, Patterns of Failure, and Acute Haematologic Toxicity of Image-Guided Volumetric Modulated Arc Therapy (IG-VMAT) in the Definitive Treatment of Locally Advanced Carcinoma Cervix

Bajpai

Early Clinical Outcomes, Patterns of Failure, and Acute Haematologic Toxicity of Image-Guided Volumetric Modulated Arc Therapy (IG-VMAT) in the Definitive Treatment of Locally Advanced Carcinoma Cervix Thumbnail


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Abstract

Purpose:To evaluate clinical outcomes and failure patterns in patients with locally advanced cervical cancer (LACC) treated definitively using image-guided volumetric-modulated arc therapy (IG-VMAT).Methods and materials:This retrospective review included 18 consecutively treated patients with LACC. Treatment consisted of IG-VMAT and concurrent chemotherapy followed by intracavitary radiotherapy. The primary end points were overall survival (OS) and disease-free survival (DFS). Acute haematologic toxicity was evaluated using Radiation Therapy Oncology Group (RTOG) criteria.Results:A total of 16 patients were either stage IIB or IIIB and the median follow-up was 30.5 months (interquartile range: 13-36.25 months). The 2-year DFS was 63.3% (95% confidence interval [CI]: 52.8%-72.4%) and 2-year OS was 72.2% (95% CI: 62.1%-80.5%). There were 7 treatment failures, predominantly in-field. Acute haematologic toxicity was low.Conclusions:IG-VMAT is associated with favourable outcomes for patients with LACC.

Acceptance Date May 22, 2018
Publication Date Jun 27, 2018
Journal Clinical Medicine Insights : Oncology
Print ISSN 1179-5549
Publisher SAGE Publications
Pages 1179554918783990 - 1179554918783990
DOI https://doi.org/10.1177/1179554918783990
Keywords Volumetric-modulated arc therapy, image guidance, cervical carcinoma, intensity-modulated radiotherapy, concurrent chemoradiation
Publisher URL https://doi.org/10.1177/1179554918783990

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