Kalra, S, Silman, A, Akman-Demir, G, Bohlega, S, Borhani-Haghighi, A, Constantinescu, CS, Houman, H, Mahr, A, Salvarani, C, Sfikakis, PP, Siva, A and Al-Araji, A (2014) Diagnosis and management of Neuro-Behçet's disease: international consensus recommendations. Journal of Neurology, 261 (9). 1662 - 1676.

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Abstract

Neuro-Behçet's disease (NBD) is one of the more serious manifestations of Behçet's disease (BD), which is a relapsing inflammatory multisystem disease with an interesting epidemiology. Though NBD is relatively uncommon, being potentially treatable, neurologists need to consider it in the differential diagnosis of inflammatory, infective, or demyelinating CNS disorders. Evidence-based information on key issues of NBD diagnosis and management is scarce, and planning for such studies is challenging. We therefore initiated this project to develop expert consensus recommendations that might be helpful to neurologists and other clinicians, created through an extensive literature review and wide consultations with an international advisory panel, followed by a Delphi exercise. We agreed on consensus criteria for the diagnosis of NBD with two levels of certainty in addition to recommendations on when to consider NBD in a neurological patient, and on the use of various paraclinical tests. The management recommendations included treatment of the parenchymal NBD and cerebral venous thrombosis, the use of disease modifying therapies, prognostic factors, outcome measures, and headache in BD. Future studies are needed to validate the proposed criteria and provide evidence-based treatments.

Item Type: Article
Additional Information: © The Author(s) 2013 Open Access This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
Uncontrolled Keywords: Behcet Syndrome, Consensus, Diagnosis, Differential, Evidence-Based Practice, Humans, Intracranial Thrombosis, Venous Thrombosis
Subjects: R Medicine > R Medicine (General)
R Medicine > RC Internal medicine > RC346 Neurology. Diseases of the nervous system, including speech disorders
Divisions: Faculty of Medicine and Health Sciences > Institute for Science and Technology in Medicine
Related URLs:
Depositing User: Symplectic
Date Deposited: 02 Apr 2019 10:29
Last Modified: 02 Apr 2019 10:29
URI: http://eprints.keele.ac.uk/id/eprint/6144

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