Madsen, C, Goñi Moreno, A, P, U, Palchick, Z, Roehner, N, Atallah, C, Bartley, B, Choi, K, Cox, RS, Gorochowski, T, Grünberg, R, Macklin, C, McLaughlin, J, Meng, X, Nguyen, T, Pocock, M, Samineni, M, Scott-Brown, J, Tarter, Y, Zhang, M, Zhang, Z, Zundel, Z, Beal, J, Bissell, M, Clancy, K, Gennari, JH, Misirli, G ORCID: https://orcid.org/0000-0002-2454-7188, Myers, C, Oberortner, E, Sauro, H and Wipat, A (2019) Synthetic Biology Open Language (SBOL) Version 2.3. Journal of Integrative Bioinformatics.

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Abstract

Synthetic biology builds upon the techniques and successes of genetics, molecular biology, and metabolic engineering by applying engineering principles to the design of biological systems. The field still faces substantial challenges, including long development times, high rates of failure, and poor reproducibility. One method to ameliorate these problems is to improve the exchange of information about designed systems between laboratories. The synthetic biology open language (SBOL) has been developed as a standard to support the specification and exchange of biological design information in synthetic biology, filling a need not satisfied by other pre-existing standards. This document details version 2.3.0 of SBOL, which builds upon version 2.2.0 published in last year's JIB Standards in Systems Biology special issue. In particular, SBOL 2.3.0 includes means of succinctly representing sequence modifications, such as insertion, deletion, and replacement, an extension to support organization and attachment of experimental data derived from designs, and an extension for describing numerical parameters of design elements. The new version also includes specifying types of synthetic biology activities, unambiguous locations for sequences with multiple encodings, refinement of a number of validation rules, improved figures and examples, and clarification on a number of issues related to the use of external ontology terms.

Item Type: Article
Additional Information: This is the final published version of the article (version of record). It first appeared online via Universitat Bielefeld / De Gruyter at https://doi.org/10.1515/jib-2019-0025 - please refer to any applicable terms of use of the publisher.
Uncontrolled Keywords: Standards, Synthetic Biology, Synthetic Biology Open Language
Subjects: Q Science > QA Mathematics > QA75 Electronic computers. Computer science
R Medicine > R Medicine (General)
Divisions: Faculty of Natural Sciences > School of Computing and Maths
Related URLs:
Depositing User: Symplectic
Date Deposited: 18 Jun 2019 13:41
Last Modified: 18 Jun 2019 13:43
URI: http://eprints.keele.ac.uk/id/eprint/6497

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