Wu, P ORCID: https://orcid.org/0000-0003-0011-5636, Mamas, M ORCID: https://orcid.org/0000-0001-9241-8890 and Gulati, M (2019) Pregnancy as a Predictor of Maternal Cardiovascular Disease: The era of CardioObstetrics. Journal of Women's Health. (In Press)

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Abstract

Globally, cardiovascular disease is the most common cause of mortality in women accounting for 1 in 3 deaths. There remains an under recognition of cardiovascular disease as well as a lack of awareness of risk in women. Promotion of cardiovascular disease prevention is essential, but the current risk assessment tools do not incorporate any sex-specific cardiovascular risk factors. There is increasing recognition of sex-specific risk factors that appear during pregnancy that are associated with cardiovascular disease. These adverse pregnancy outcomes include preeclampsia, gestational hypertension, preterm birth, gestational diabetes, delivery of a small-for-gestational-age infant, miscarriage and high parity number. Although the underlying biological mechanism for these association remains to be elucidated, current international guidelines are beginning to recommend the inclusion of adverse pregnancy outcomes in the assessment of cardiovascular disease risk in women. This review summarizes the evidence for the association between adverse pregnancy outcomes and future cardiovascular disease. It also highlights the importance of considering adverse pregnancy outcomes in the cardiovascular risk assessment, specifically in young women, allowing for targeted lifestyle modifying interventions with the potential to alter their risk trajectory and improve their long-term cardiovascular health.

Item Type: Article
Additional Information: This is the accepted author manuscript (AAM). The final published version (version of record) will be available online via Mary Ann Liebert at https://home.liebertpub.com/publications/journal-of-womens-health/42 - please refer to any applicable terms of use of the publisher.
Uncontrolled Keywords: cardiovascular disease, pregnancy, gestational hypertension, preterm birth, gestational diabetes
Subjects: R Medicine > RC Internal medicine > RC666 Diseases of the circulatory (Cardiovascular) system
Divisions: Faculty of Medicine and Health Sciences > Primary Care Health Sciences
Depositing User: Symplectic
Date Deposited: 10 Jul 2019 10:47
Last Modified: 10 Jul 2019 10:50
URI: http://eprints.keele.ac.uk/id/eprint/6570

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