Yan, Z, Yu, D ORCID: https://orcid.org/0000-0002-8449-7725, Cai, Y, Shang, J, Qin, R, Xiao, J, Zhao, B, Zhao, Z and Simmons, D (2019) Triglyceride Glucose Index Predicting Cardiovascular Mortality in Chinese Initiating Peritoneal Dialysis: A Cohort Study. Kidney and Blood Pressure Research, 44 (4). pp. 669-678.

[img] Text
TyG and CVD death in PD clean copy 20190515.docx - Accepted Version
Available under License Creative Commons Attribution Non-commercial No Derivatives.

Download (177kB)

Abstract

Background:
Insulin resistance (IR) is increased among people with end-stage renal disease (ESRD). The Triglyceride glucose (TyG) index is a marker of IR and is also associated with the prognosis of cardiovascular disease among patients initiating peritoneal dialysis (PD). This study was aimed at examining the associations between TyG index and cardiovascular deaths in patients initiating PD.

Methods:
Three thousand fifty-four patients initiating PD between 2007 and 2014 were included in a prospective cohort derived from Henan PD Registry, TyG index alongside other baseline characteristics were measured when ESRD patients initiated PD. Logistic regression adjusting for age, gender, and major cardiovascular risk factors estimated the association between TyG index and subsequent cardiovascular mortality within 2 years since the initiation of PD.

Results:
TyG index was positively associated with cardiovascular mortality: adjusted incidence rates ratio (95% CI) comparing the highest vs. lowest TyG index quartile was 2.32 (2.12–2.55) in all, 2.22 (2.01–2.46) in those with body mass index (BMI) <25 kg/m2, and 2.82 (2.24–3.54) in those with BMI ≥25 kg/m2, respectively. Linear dose-response relationships were revealed in all and by BMI.

Conclusions:
TyG index might be a prognostic factor in predicting cardiovascular mortality among patients initiating PD.

Item Type: Article
Additional Information: This is the accepted author manuscript (AAM). The final published version (version of record) is available online via S. Karger AG at https://doi.org/10.1159/000500979 - please refer to any applicable terms of use of the publisher.
Uncontrolled Keywords: Triglyceride glucose index, Cardiovascular diseases, Mortality, Peritoneal dialysis, Prognostic factor
Subjects: R Medicine > R Medicine (General)
R Medicine > RC Internal medicine
Divisions: Faculty of Medicine and Health Sciences > Primary Care Health Sciences
Depositing User: Symplectic
Date Deposited: 23 Jul 2019 15:21
Last Modified: 23 Sep 2019 11:15
URI: http://eprints.keele.ac.uk/id/eprint/6581

Actions (login required)

View Item View Item