Borovac, JA, Kwok, CS ORCID: https://orcid.org/0000-0001-7047-1586, Iliescu, C, Lee, HJ, Kim, PY, Palaskas, NL, Zaman, A, Butler, R, Lopez-Mattei, JC and Mamas, MA ORCID: https://orcid.org/0000-0001-9241-8890 (2019) Percutaneous Coronary Intervention and Outcomes in Patients with Lymphoma in the United States (Nationwide Inpatient Sample [NIS] analysis). The American Journal of Cardiology.

[img] Text
M Mamas - Percutaneous coronary intervention and outcomes in patients....pdf - Accepted Version
Restricted to Repository staff only until 24 July 2020.
Available under License Creative Commons Attribution Non-commercial No Derivatives.

Download (852kB)

Abstract

Characteristics and outcomes of patients with lymphoma undergoing PCI are unknown. Therefore, we analyzed clinical characteristics and outcomes in patients that underwent percutaneous coronary intervention (PCI) and had a concomitant diagnosis of Hodgkin’s (HL) or non-Hodgkin’s (NHL) lymphoma. We analyzed patients with and without lymphoma diagnosis from the Nationwide Inpatient Sample in the US who underwent PCI procedure during 2004-2014. Multivariable regression analysis was performed to examine the association between lymphoma diagnosis and clinical outcomes post-PCI including shortterm complications and in-hospital mortality. A total of 7,119,539 PCI procedures were included in the analysis and 18,052 patients had a diagnosis of lymphoma (0.25%). These patients were likely to experience in-hospital mortality (OR 1.39, 95%CI 1.25-1.54), stroke or transient ischemic attack (TIA) (OR 1.75, 95%CI 1.61-1.90), and any in-hospital complication (OR 1.31, 95%CI 1.25-1.37), following PCI. In the lymphoma subtypeanalysis, diagnosis of HL was associated with an increased odds of in-hospital death (OR 1.40, 95% CI 1.24-1.56), any in-hospital complication (OR 1.31, 95% CI 1.25-1.38), bleeding complications (OR 1.12 95% CI 1.05-1.20) and vascular complications (OR 1.13 95%CI 1.06-1.20) while these odds were not significantly associated with NHL diagnosis. Finally, both types of lymphoma were associated with an increased odds of stroke/TIA following PCI (OR 1.82, 95% CI 1.67-1.99 and OR 1.31, 95% CI 1.05-1.63, respectively). In conclusion, while the prevalence of lymphoma in the observed PCI cohort was low, a diagnosis of lymphoma was associated with an adverse prognosis following PCI, primarily in patients with the HL diagnosis.

Item Type: Article
Additional Information: The final published version of this accepted manuscript is available online at https://www.sciencedirect.com/science/article/pii/S0002914919308124
Uncontrolled Keywords: Lymphoma; Coronary Artery Disease; Complications; Mortality
Subjects: R Medicine > R Medicine (General)
Divisions: Faculty of Medicine and Health Sciences > Primary Care Health Sciences
Depositing User: Symplectic
Date Deposited: 29 Jul 2019 08:14
Last Modified: 30 Jul 2019 14:54
URI: http://eprints.keele.ac.uk/id/eprint/6598

Actions (login required)

View Item View Item