Ditchfield, N, Carroll, WD and Gilchrist, FJ (2019) Unwarranted use of intravenous aminoglycosides at UK paediatric cystic fibrosis centres. Journal of Cystic Fibrosis.

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Ditchfield JCF June 2019 Manuscript 2.docx - Accepted Version
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Abstract

Highlights

IV aminoglycosides are frequently used to treat infective exacerbations in CF due to efficacy against PA.

The side effects of aminoglycosides include nephrotoxicity, ototoxicity and vestibulotoxicity.

More than one third of UK CF centres use tobramycin to treat pulmonary exacerbations in children who have never isolated PA.

More than one half of UK CF centres use tobramycin to treat pulmonary exacerbations in children free of PA for >12 months.

IV aminoglycosides should be reserved for infective exacerbations in which PA is confirmed or strongly suspected.

Item Type: Article
Additional Information: This is the accepted author manuscript (AAM). The final published version (version of record) is available online via Elsevier at http://doi.org/10.1016/j.jcf.2019.09.004 - please refer to any applicable terms of use of the publisher.
Uncontrolled Keywords: Acute kidney injury, Aminoglycosides, Chronic kidney disease, Cystic fibrosis, Pseudomonas aeruginosa
Subjects: R Medicine > RC Internal medicine > RC705 Diseases of the respiratory system
R Medicine > RC Internal medicine > RC902 Nephrology
Divisions: Faculty of Medicine and Health Sciences > Institute for Applied Clinical Sciences
Related URLs:
Depositing User: Symplectic
Date Deposited: 11 Oct 2019 08:16
Last Modified: 11 Oct 2019 08:18
URI: http://eprints.keele.ac.uk/id/eprint/7012

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