Sara C Martinez
Percutaneous Coronary Intervention Outcomes in Patients with Rheumatoid Arthritis, Systemic Lupus Erythematosus and Systemic sclerosis
Martinez, Sara C; Mohamed, Mohamed; Potts, Jessica; Abhishek, Abhishek; Roddy, Edward; Savage, Michael; Bharadwaj, Aditya; Kwok, Chun Shing; Bagur, Rodrigo; Mamas, Mamas A
Authors
Mohamed Mohamed
Jessica Potts
Abhishek Abhishek
Edward Roddy e.roddy@keele.ac.uk
Michael Savage
Aditya Bharadwaj
Chun Shing Kwok
Rodrigo Bagur
Mamas Mamas m.mamas@keele.ac.uk
Abstract
Objective
Patients with autoimmune rheumatic disease (AIRD) are at an increased risk of coronary artery disease. The present study sought to examine the prevalence and outcomes of AIRD patients undergoing percutaneous coronary intervention (PCI) from a national perspective.
Methods
All PCI-related hospitalizations recorded in the US National Inpatient Sample (2004–2014) were included, stratified into four groups: no AIRD, RA, SLE and SSc. We examined the prevalence of AIRD subtypes and assessed their association with in-hospital adverse events using multivariable logistic regression [odds ratios (OR) (95% CI)].
Results
Patients with AIRD represented 1.4% (n?=?90 469) of PCI hospitalizations. The prevalence of RA increased from 0.8% in 2004 to 1.4% in 2014, but other AIRD subtypes remained stable. In multivariable analysis, the adjusted odds ratio (aOR) of in-hospital complications [aOR any complication 1.13 (95% CI 1.01, 1.26), all-cause mortality 1.32 (1.03, 1.71), bleeding 1.50 (1.30, 1.74), stroke 1.36 (1.14, 1.62)] were significantly higher in patients with SSc compared with those without AIRD. There was no difference in complications between the SLE and RA groups and those without AIRD, except higher odds of bleeding in SLE patients [aOR 1.19 (95% CI 1.09, 1.29)] and reduced odds of all-cause mortality in RA patients [aOR 0.79 (95% CI 0.70, 0.88)].
Conclusion
In a nationwide cohort of US hospitalizations, we demonstrate increased rates of all adverse clinical outcomes following PCI in people with SSc and increased bleeding in SLE. Management of such patients should involve a multiteam approach with rheumatologists.
Journal Article Type | Article |
---|---|
Acceptance Date | Nov 29, 2019 |
Online Publication Date | Jan 28, 2020 |
Publication Date | 2020-09 |
Journal | Rheumatology |
Print ISSN | 1462-0324 |
Publisher | Oxford University Press |
Peer Reviewed | Peer Reviewed |
Volume | 59 |
Issue | 9 |
Pages | 2512-2522 |
DOI | https://doi.org/10.1093/rheumatology/kez639 |
Keywords | Percutaneous, coronary intervention outcomes, rheumatoid arthritis, systematic lupus erythematosus, systematic sclerosis. |
Publisher URL | https://doi.org/10.1093/rheumatology/kez639 |
Files
FINAL SUBMISSION PROOF.pdf
(579 Kb)
PDF
Publisher Licence URL
https://creativecommons.org/licenses/by-nc/4.0/
You might also like
A Genome-Wide Association Analysis of 2,622,830 Individuals Reveals New Pathogenic Pathways in Gout
(2022)
Presentation / Conference
Downloadable Citations
About Keele Repository
Administrator e-mail: research.openaccess@keele.ac.uk
This application uses the following open-source libraries:
SheetJS Community Edition
Apache License Version 2.0 (http://www.apache.org/licenses/)
PDF.js
Apache License Version 2.0 (http://www.apache.org/licenses/)
Font Awesome
SIL OFL 1.1 (http://scripts.sil.org/OFL)
MIT License (http://opensource.org/licenses/mit-license.html)
CC BY 3.0 ( http://creativecommons.org/licenses/by/3.0/)
Powered by Worktribe © 2024
Advanced Search