The antiapoptotic RBM5/LUCA-15/H37 gene and its role in apoptosis and human cancer: Research update

Maarabouni, Mirna M; Williams, Gwyn T

doi:10.1100/tsw.2006.268

The antiapoptotic RBM5/LUCA-15/H37 gene and its role in apoptosis and human cancer: Research update

Maarabouni, Mirna M; Williams, Gwyn T

Authors

DR Mirna Maarabouni m.m.maarabouni@keele.ac.uk

Gwyn T Williams

Abstract

The candidate tumour-suppressor gene, LUCA-15/RBM5/H37, maps to the lung cancer tumour-suppressor locus 3p21.3. The LUCA-15 gene locus encodes at least four alternatively spliced transcripts that have been shown to function as regulators of apoptosis, a fact which may have major significance in tumour regulation. This review highlights recent evidence that further implicates the LUCA-15 locus in the control of apoptosis and cell proliferation, and focuses on the observations that confirm the tumour-suppressor activity of this gene.

Journal Article Type	Article
Acceptance Date	Dec 28, 2006
Publication Date	Dec 28, 2006
Publicly Available Date	May 26, 2023
Journal	Scientific World Journal
Print ISSN	2356-6140
Publisher	Hindawi
Pages	1705 - 1712
ISBN	1537744X
DOI	https://doi.org/10.1100/tsw.2006.268
Keywords	Apoptosis (D017209), Cell Cycle Proteins (D018797), Cell Proliferation (D049109), DNA-Binding Proteins (D004268), Gene Expression Regulation, Neoplastic (D015972), Genes, Tumor Suppressor (D016147), Humans (D006801), Lung Neoplasms (D008175), RNA-Binding
Publisher URL	https://www.hindawi.com/journals/tswj/2006/819835/