Hall, A, Stubbs, B, Mamas, MA ORCID: https://orcid.org/0000-0001-9241-8890 and Myint, PK (2016) Association between osteoarthritis and cardiovascular disease: systematic review and meta-analysis. European Journal of Preventive Cardiology, 23 (9). pp. 938-946.

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Abstract

Background
To examine for a possible relationship between osteoarthritis and cardiovascular disease.

Design
A systematic review and meta-analysis.

Methods
Published and unpublished literature from: MEDLINE, EMBASE, CINAHL, the Cochrane Library, OpenGrey and clinical trial registers. Search to 22 November 2014. Cohort, case-control, randomised and non-randomised controlled trial papers reporting the prevalence of cardiovascular disease in osteoarthritis were included.

Results
Fifteen studies with 32,278,744 individuals were eligible. Pooled prevalence for overall cardiovascular disease pathology in people with osteoarthritis was 38.4% (95% confidence interval (CI): 37.2% to 39.6%). Individuals with osteoarthritis were almost three times as likely to have heart failure (relative risk (RR): 2.80; 95% CI: 2.25 to 3.49) or ischaemic heart disease (RR: 1.78; 95% CI: 1.18 to 2.69) compared with matched non-osteoarthritis cohorts. No significant difference was detected between the two groups for the risk of experiencing myocardial infarction or stroke. There was a three-fold decrease in the risk of experiencing a transient ischaemic attack in the osteoarthritis cohort compared with the non-osteoarthritis group.

Conclusions
Prevalence of cardiovascular disease in patients with osteoarthritis is significant. There was an observed increased risk of incident heart failure and ischaemic heart disease in people with osteoarthritis compared with matched controls. However, the relationship between osteoarthritis and cardiovascular disease is not straightforward and there is a need to better understand the potential common pathways linking pathophysiological mechanisms.

Item Type: Article
Additional Information: This is the accepted author manuscript (AAM). The final published version (version of record) is available online via Sage at - http://dx.doi.org/10.1177/2047487315610663 - please refer to any applicable terms of use of the publisher.
Uncontrolled Keywords: osteoarthritis, cardiovascular disease, cerebrovascular disease, myocardial infarction, hypertension
Subjects: R Medicine > R Medicine (General)
Divisions: Faculty of Medicine and Health Sciences > Institute for Science and Technology in Medicine
Depositing User: Symplectic
Date Deposited: 21 Sep 2015 10:27
Last Modified: 11 Apr 2019 15:54
URI: http://eprints.keele.ac.uk/id/eprint/924

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