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RANK, RANKL and osteoprotegerin in bone biology and disease.

Abstract

Upon the discovery of RANK, RANKL and OPG in the late 1990s, their importance in the maintenance of the skeletal structure and their dramatic role in bone disease were largely unexpected. In recent years the understanding of these proteins, in particular their regulation, has greatly increased. This review aims to bring the interested reader up to date with the latest news and views on the mechanisms controlling bone resorption in normal and pathological conditions.

Acceptance Date Feb 24, 2009
Publication Date Mar 10, 2009
Journal Current Reviews in Musculoskeletal Medicine
Print ISSN 1935-973X
Publisher Springer Verlag
Pages 56 -64
Keywords RANK, RANKL, OPG, bone disease
Publisher URL http://dx.doi.org/10.1007%2Fs12178-009-9046-7

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