Ponts, N, Yang, J, Chung, DW, Prudhomme, J, Girke, T, Horrocks, P ORCID: 0000-0003-3981-0732 and Le Roch, KG (2008) Deciphering the ubiquitin-mediated pathway in apicomplexan parasites: a potential strategy to interfere with parasite virulence. PLoS One, 3 (6). e2386 - ?. ISSN 1932-6203

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Abstract

Reversible modification of proteins through the attachment of ubiquitin or ubiquitin-like modifiers is an essential post-translational regulatory mechanism in eukaryotes. The conjugation of ubiquitin or ubiquitin-like proteins has been demonstrated to play roles in growth, adaptation and homeostasis in all eukaryotes, with perturbation of ubiquitin-mediated systems associated with the pathogenesis of many human diseases, including cancer and neurodegenerative disorders.

Item Type: Article
Uncontrolled Keywords: Apicomplexa, Plasmodium, Protein domains, Toxoplasma gondii, Ligases, Ubiquitin ligases, Cell cycle and cell division, Conjugated proteins
Subjects: Q Science > QH Natural history > QH301 Biology
Divisions: Faculty of Natural Sciences > School of Life Sciences
Related URLs:
Depositing User: Symplectic
Date Deposited: 26 Nov 2014 13:16
Last Modified: 23 Aug 2018 13:57
URI: http://eprints.keele.ac.uk/id/eprint/99

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