A synthesis of C-glycosidic multivalent mannosides suitable for divergent functionalized conjugation

Miller

doi:10.1016/j.tetlet.2011.04.047

A synthesis of C-glycosidic multivalent mannosides suitable for divergent functionalized conjugation

Miller

Authors

Gavin Miller g.j.miller@keele.ac.uk

Abstract

Divergent synthesis of two novel C-glycosidic multivalent mannosides derived from a common trivalent C-mannosyl carboxylate-terminated intermediate is described. This illustrates synthesis of multivalent C-glycosidic architectures bearing variable extended functionalized tethers. One such tether incorporates an embedded fluorescent unit providing a C-mannosyl multivalent epitope offering potential applications through further conjugation or immobilization.

Acceptance Date	Apr 11, 2011
Publication Date	Apr 18, 2011
Journal	Tetrahedron Letters
Print ISSN	0040-4039
Publisher	Elsevier
Pages	3216 - 3218
DOI	https://doi.org/10.1016/j.tetlet.2011.04.047
Keywords	C-Glycosides, Multivalency, Carbohydrates, Glycobiology, Glycoconjugation
Publisher URL	https://doi.org/10.1016/j.tetlet.2011.04.047