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Social Disadvantage Is Associated With Lower Vitamin D Levels in Older People and There Is No Surrogate for Its Measurement

Heald, Adrian H.; Anderson, Simon G.; Scargill, Jonathan J.; Short, Andrea; Holland, David; Khan, Adnan; Fryer, Anthony A.; Donn, Rachelle P.; Livingston, Mark

Social Disadvantage Is Associated With Lower Vitamin D Levels in Older People and There Is No Surrogate for Its Measurement Thumbnail


Authors

Adrian H. Heald

Simon G. Anderson

Jonathan J. Scargill

Andrea Short

David Holland

Adnan Khan

Rachelle P. Donn

Mark Livingston



Abstract

There is increasing evidence concerning adverse health consequences of low vitamin D levels. We determined whether there is any surrogate for measuring vitamin D in people older than 70 years and the relation between index of multiple deprivation (IMD) and vitamin D levels. Methods: Blood samples from 241 patients were included in this analysis. Concurrent measurements for 25-hydroxyvitamin D (25(OH)D), parathyroid hormone (PTH), and bone profile are reported. Results: The prevalence of total vitamin D insufficiency/deficiency (defined as total vitamin D <50 nmol/L) was 57.5% overall. Even for patients with vitamin D deficiency, a significant proportion had PTH, normal calcium, phosphate, and alkaline phosphatase levels. For patients with vitamin D <25 nmol/L, 62.7% had a PTH within reference range, 83.1% had normal serum-adjusted calcium, 80.6% had normal phosphate, and 85.1% had a normal serum alkaline phosphatase. With increasing quintiles of IMD, there was a 22% increased risk of vitamin D deficiency/insufficiency from quintiles 1 to 5, in age- and sex-adjusted logistic regression models (odds ratio [OR] = 1.22, 95% confidence interval [1.01, 1.47]; p = .034). Conclusion: No other parameter is currently adequate for screening for vitamin D deficiency in older people. A higher IMD is associated with lower vitamin D levels in older people.

Acceptance Date Jan 1, 2017
Publication Date Jan 1, 2017
Publicly Available Date Mar 28, 2024
Journal Gerontology and Geriatric Medicine
Print ISSN 2333-7214
Publisher SAGE Publications
DOI https://doi.org/10.1177/2333721417697843
Keywords vitamin D deficiency; social deprivation; screening; older people
Publisher URL https://doi.org/10.1177%2F2333721417697843

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