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An investigation into the role of dendrimers as potential enhancers of the dermal delivery of topically applied chlorhexidine

An investigation into the role of dendrimers as potential enhancers of the dermal delivery of topically applied chlorhexidine Thumbnail


Abstract

The reduction of bacteria on the skin results in prophylactic and therapeutic benefits by reducing the occurrence of skin infections. Currently, chlorhexidine digluconate, a conventional topical antiseptic, permeates the skin poorly leaving viable opportunistic pathogens below the superficial layers of the stratum corneum. The aim of this study was to use polyamidoamine (PAMAM) dendrimers to enhance the topical delivery of chlorhexidine digluconate to improve its antimicrobial efficacy.

Publicly Available Date Mar 29, 2024
Keywords bacteria skin infections polyamidoamine dendrimers PAMAM chlorhexidine digluconate

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