Skip to main content

Research Repository

Advanced Search

Mechanotransduction is required for establishing and maintaining mature inner hair cells and regulating efferent innervation

Mechanotransduction is required for establishing and maintaining mature inner hair cells and regulating efferent innervation Thumbnail


Abstract

In the adult auditory organ, mechanoelectrical transducer (MET) channels are essential for transducing acoustic stimuli into electrical signals. In the absence of incoming sound, a fraction of the MET channels on top of the sensory hair cells are open, resulting in a sustained depolarizing current. By genetically manipulating the in vivo expression of molecular components of the MET apparatus, we show that during pre-hearing stages the MET current is essential for establishing the electrophysiological properties of mature inner hair cells (IHCs). If the MET current is abolished in adult IHCs, they revert into cells showing electrical and morphological features characteristic of pre-hearing IHCs, including the re-establishment of cholinergic efferent innervation. The MET current is thus critical for the maintenance of the functional properties of adult IHCs, implying a degree of plasticity in the mature auditory system in response to the absence of normal transduction of acoustic signals.

Acceptance Date Aug 21, 2018
Publication Date Oct 1, 2018
Journal Nature Communications
Print ISSN 2041-1723
DOI https://doi.org/10.1038/s41467-018-06307
Publisher URL http://doi.org/10.1038/s41467-018-06307

Files







Downloadable Citations