Dr Susan Hunter s.m.hunter@keele.ac.uk
Functional Strength Training and Movement Performance Therapy for Upper Limb Recovery Early Poststroke-Efficacy, Neural Correlates, Predictive Markers, and Cost-Effectiveness: FAST-INdiCATE Trial.
Hunter
Authors
Abstract
Background: Variation in physiological deficits underlying upper limb paresis after stroke could influence how people recover and to which physical therapy they best respond. Objectives: To determine whether functional strength training (FST) improves upper limb recovery more than movement performance therapy (MPT). To identify: (a) neural correlates of response and (b) whether pre-intervention neural characteristics predict response. Design: Explanatory investigations within a randomised, controlled, observer-blind, and multicentre trial. Randomisation was computer-generated and concealed by an independent facility until baseline measures were completed. Primary time point was outcome, after the 6-week intervention phase. Follow-up was at 6?months after stroke. Participants: With some voluntary muscle contraction in the paretic upper limb, not full dexterity, when recruited up to 60?days after an anterior cerebral circulation territory stroke. Interventions: Conventional physical therapy (CPT) plus either MPT or FST for up to 90?min-a-day, 5?days-a-week for 6?weeks. FST was "hands-off" progressive resistive exercise cemented into functional task training. MPT was "hands-on" sensory/facilitation techniques for smooth and accurate movement. Outcomes: The primary efficacy measure was the Action Research Arm Test (ARAT). Neural measures: fractional anisotropy (FA) corpus callosum midline; asymmetry of corticospinal tracts FA; and resting motor threshold (RMT) of motor-evoked potentials. Analysis: Covariance models tested ARAT change from baseline. At outcome: correlation coefficients assessed relationship between change in ARAT and neural measures; an interaction term assessed whether baseline neural characteristics predicted response. Results: 288 Participants had: mean age of 72.2 (SD 12.5) years and mean ARAT 25.5 (18.2). For 240 participants with ARAT at baseline and outcome the mean change was 9.70 (11.72) for FST?+?CPT and 7.90 (9.18) for MPT?+?CPT, which did not differ statistically (p?=?0.298). Correlations between ARAT change scores and baseline neural values were between 0.199, p?=?0.320 for MPT?+?CPT RMT (n?=?27) and -0.147, p?=?0.385 for asymmetry of corticospinal tracts FA (n?=?37). Interaction effects between neural values and ARAT change between baseline and outcome were not statistically significant. Conclusions: There was no significant difference in upper limb improvement between FST and MPT. Baseline neural measures did not correlate with upper limb recovery or predict therapy response. Trial registration: Current Controlled Trials: ISRCT 19090862, http://www.controlled-trials.com.
Acceptance Date | Dec 19, 2017 |
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Publication Date | Jan 25, 2018 |
Journal | Frontiers in Neurology |
Publisher | Frontiers Media |
Pages | 733 - ? |
DOI | https://doi.org/10.3389/fneur.2017.00733 |
Keywords | strength training; upper limb recovery; stroke |
Publisher URL | https://www.frontiersin.org/articles/10.3389/fneur.2017.00733/full |
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