Adam P Hitchcock
Correlative Spectromicroscopy and Tomography for Biomedical Applications involving Electron, Ion, and Soft X-ray Microscopies
Hitchcock, Adam P; Wang, Xiaoyue; Grandfield, Kathryn; Everett, James; Collingwood, Joanna F; Telling, Neil D
Authors
Xiaoyue Wang
Kathryn Grandfield
James Everett j.everett@keele.ac.uk
Joanna F Collingwood
Neil Telling n.d.telling@keele.ac.uk
Abstract
Many important scientific and technical problems are best addressed using multiple, microscopy-based analytical techniques that combine the strengths of complementary methods. Here, we provide two examples from biomedical challenges: unravelling the attachment zone between dental implants and bone, and uncovering the mechanism of Alzheimer's disease. They combine synchrotron-based scanning transmission X-ray microscopy (STXM) with transmission electron microscopy ((S)TEM), electron tomography (ET), EELS tomography, and/or atom probe tomography (APT). STXM provides X-ray absorption based chemical sensitivity at mesoscale resolution (10–30 nm), which complements higher spatial resolution electron microscopy and APT.
Journal Article Type | Article |
---|---|
Acceptance Date | Mar 14, 2019 |
Publication Date | Mar 14, 2019 |
Journal | Microscopy Today |
Print ISSN | 1551-9295 |
Publisher | Cambridge University Press |
Peer Reviewed | Peer Reviewed |
Volume | 27 |
Issue | 2 |
DOI | https://doi.org/10.1017/S1551929518001256 |
Keywords | scanning transmission X-ray microscopy; scanning transmission electron microscopy; atom probe tomography; titanium implants; Alzheimer's disease |
Publisher URL | https://www.cambridge.org/core/journals/microscopy-today/article/correlative-spectromicroscopy-and-tomography-for-biomedical-applications-involving-electron-ion-and-soft-xray-microscopies/1CFAC59353E5E2F0CBF685EE73AAB7C1 |
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