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Classification of fracture and non-fracture groups by analysis of coherent X-ray scatter

Dicken, AJ; Evans, JPO; Rogers, KD; Stone, N; Greenwood, CE; Godber, SX; Clement, JG; Lyburn, ID; Martin, RM; Zioupos, P

Classification of fracture and non-fracture groups by analysis of coherent X-ray scatter Thumbnail


Authors

AJ Dicken

JPO Evans

KD Rogers

N Stone

SX Godber

JG Clement

ID Lyburn

RM Martin

P Zioupos



Abstract

Osteoporotic fractures present a significant social and economic burden, which is set to rise
commensurately with the aging population. Greater understanding of the physicochemical differences
between osteoporotic and normal conditions will facilitate the development of diagnostic technologies
with increased performance and treatments with increased efficacy. Using coherent X-ray scattering we
have evaluated a population of 108 ex vivo human bone samples comprised of non-fracture and fracture
groups. Principal component fed linear discriminant analysis was used to develop a classification
model to discern each condition resulting in a sensitivity and specificity of 93% and 91%, respectively.
Evaluating the coherent X-ray scatter differences from each condition supports the hypothesis that a
causal physicochemical change has occurred in the fracture group. This work is a critical step along the
path towards developing an in vivo diagnostic tool for fracture risk prediction.

Journal Article Type Article
Acceptance Date Jun 10, 2016
Online Publication Date Jul 1, 2016
Publication Date Jul 1, 2016
Publicly Available Date Mar 28, 2024
Journal Scientific Reports
Print ISSN 2045-2322
Publisher Nature Publishing Group
Peer Reviewed Peer Reviewed
Volume 6
Article Number 29011
DOI https://doi.org/10.1038/srep29011
Publisher URL https://www.nature.com/articles/srep29011#abstract

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