Skip to main content

Research Repository

Advanced Search

Oncosuppressive role of p53-induced miR-205 in triple negative breast cancer.

Di Leva

Oncosuppressive role of p53-induced miR-205 in triple negative breast cancer. Thumbnail


Authors



Abstract

An increasing body of evidence highlights an intriguing interaction between microRNAs and transcriptional factors involved in determining cell fate, including the well known "genome guardian" p53. Here we show that miR-205, oncosuppressive microRNA lost in breast cancer, is directly transactivated by oncosuppressor p53. Moreover, evaluating miR-205 expression in a panel of cell lines belonging to the highly aggressive triple negative breast cancer (TNBC) subtype, which still lacks an effective targeted therapy and characterized by an extremely undifferentiated and mesenchymal phenotype, we demonstrated that this microRNA is critically down-expressed compared to a normal-like cell line. Re-expression of miR-205 where absent strongly reduces cell proliferation, cell cycle progression and clonogenic potential in vitro, and inhibits tumor growth in vivo, and this tumor suppressor activity is at least partially exerted through targeting of E2F1, master regulator of cell cycle progression, and LAMC1, component of extracellular matrix involved in cell adhesion, proliferation and migration.

Acceptance Date Mar 12, 2012
Publication Date Apr 19, 2012
Publicly Available Date Mar 29, 2024
Journal Molecular Oncology
Print ISSN 1574-7891
Publisher Wiley
Pages 458 - 472
DOI https://doi.org/10.1016/j.molonc.2012.03.003
Keywords miR-205; p53; E2F1; LAMC1
Publisher URL https://febs.onlinelibrary.wiley.com/doi/full/10.1016/j.molonc.2012.03.003

Files




You might also like



Downloadable Citations