Andrew M. Hammond
Gene drives to fight malaria: current state and future directions
Hammond, Andrew M.; Galizi, Roberto
Abstract
Self-propagating gene drive technologies have a number of desirable characteristics that warrant their development for the control of insect pest and vector populations, such as the malaria-transmitting mosquitoes. Theoretically easy to deploy and self-sustaining, these tools may be used to generate cost-effective interventions that benefit society without obvious bias related to wealth, age or education. Their species-specific design offers the potential to reduce environmental risks and aim to be compatible and complementary with other control strategies, potentially expediting the elimination and eradication of malaria. A number of strategies have been proposed for gene-drive based control of the malaria mosquito and recent demonstrations have shown proof-of-principle in the laboratory. Though several technical, ethical and regulatory challenges remain, none appear insurmountable if research continues in a step-wise and open manner.
Journal Article Type | Article |
---|---|
Acceptance Date | Feb 9, 2018 |
Publication Date | Feb 19, 2018 |
Publicly Available Date | May 26, 2023 |
Journal | Pathogens and Global Health |
Print ISSN | 2047-7724 |
Publisher | Taylor and Francis |
Pages | 412 - 423 |
DOI | https://doi.org/10.1080/20477724.2018.1438880 |
Keywords | Gene, Malaria, Directions |
Publisher URL | https://www.tandfonline.com/doi/full/10.1080/20477724.2018.1438880 |
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Gene drives to fight malaria current state and future directions.pdf
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Publisher Licence URL
https://creativecommons.org/licenses/by-nc-nd/4.0/
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