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Bioinformatic characterization of the Anoctamin Superfamily of Ca2+-activated ion channels and lipid scramblases

Bioinformatic characterization of the Anoctamin Superfamily of Ca2+-activated ion channels and lipid scramblases Thumbnail


Abstract

Our laboratory has developed bioinformatic strategies for identifying distant phylogenetic relationships and characterizing families and superfamilies of transport proteins. Results using these tools suggest that the Anoctamin Superfamily of cation and anion channels, as well as lipid scramblases, includes three functionally characterized families: the Anoctamin (ANO), Transmembrane Channel (TMC) and Ca2+-permeable Stress-gated Cation Channel (CSC) families; as well as four families of functionally uncharacterized proteins, which we refer to as the Anoctamin-like (ANO-L), Transmembrane Channel-like (TMC-L), and CSC-like (CSC-L1 and CSC-L2) families. We have constructed protein clusters and trees showing the relative relationships among the seven families. Topological analyses suggest that the members of these families have essentially the same topologies. Comparative examination of these homologous families provides insight into possible mechanisms of action, indicates the currently recognized organismal distributions of these proteins, and suggests drug design potential for the disease-related channel proteins.

Acceptance Date Jan 31, 2018
Publication Date Mar 26, 2018
Publicly Available Date Mar 29, 2024
Journal PLoS One
Print ISSN 1932-6203
Publisher Public Library of Science
Pages e0192851 - ?
DOI https://doi.org/10.1371/journal.pone.0192851
Keywords Bioinformatic, Anoctamin Superfamily, Ca2+-activated, ion channels, lipid scramblases.
Publisher URL https://journals.plos.org/plosone/article/authors?id=10.1371/journal.pone.0192851

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