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Calculating the sample size required for developing a clinical prediction model.

Calculating the sample size required for developing a clinical prediction model. Thumbnail


Abstract

Clinical prediction models aim to predict outcomes in individuals, to inform diagnosis or prognosis in healthcare. Hundreds of prediction models are published in the medical literature each year, yet many are developed using a dataset that is too small for the total number of participants or outcome events. This leads to inaccurate predictions and consequently incorrect healthcare decisions for some individuals. In this article, the authors provide guidance on how to calculate the sample size required to develop a clinical prediction model.

Acceptance Date Dec 19, 2019
Publication Date Mar 18, 2020
Publicly Available Date Mar 29, 2024
Journal BMJ
Print ISSN 0959-8138
Publisher BMJ Publishing Group
Pages -
DOI https://doi.org/10.1136/bmj.m441
Keywords Clinical prediction
Publisher URL https://www.bmj.com/content/368/bmj.m441

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