Fractalkine expression on human renal tubular epithelial cells: potential role in mononuclear cell adhesion

CHAKRAVORTY, S J; COCKWELL, P; GIRDLESTONE, J; BROOKS, C J; SAVAGE, C O S

doi:10.1046/j.1365-2249.2002.01906.x

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The CC chemokine, monocyte chemoattractant protein-4 (MCP-4), is an important chemoattractant for monocytes and T cells. Recent data indicate a role in renal inflammation. This study has used in situ hybridization and immunohistochemical analysis of... Read More about Potential role for monocyte chemotactic protein-4 (MCP-4) in monocyte/macrophage recruitment in acute renal inflammation.

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Immune and inflammatory human renal disease is associated with heavy mononuclear cell infiltration. The trafficking of these cells to extravascular sites is directed by local production of chemokines. Fractalkine is the first described cell-surface a... Read More about Fractalkine expression in human renal inflammation.

Chemoattraction of T cells expressing CCR5, CXCR3 and CX3CR1 by proximal tubular epithelial cell chemokines (2002)
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Background. Chemokines produced by resident renal cells promote the infiltration of leukocyte subsets. We have analysed the chemotactic responses of CD3+ peripheral blood lymphocytes (PBLs) to factors secreted by proximal tubular epithelial cells (PT... Read More about Chemoattraction of T cells expressing CCR5, CXCR3 and CX3CR1 by proximal tubular epithelial cell chemokines.

Fractalkine expression on human renal tubular epithelial cells: potential role in mononuclear cell adhesion (2002)
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Fractalkine (CX3CL1) is a transmembrane molecule with a CX3C chemokine domain attached to an extracellular mucin stalk which can induce both adhesion and migration of leucocytes. Mononuclear cell infiltration at renal tubular sites and associated tub... Read More about Fractalkine expression on human renal tubular epithelial cells: potential role in mononuclear cell adhesion.