Perera-Solis, DD, Zholobenko, VL ORCID: https://orcid.org/0000-0002-6024-0503, Whiting, A and Greenwell, HC (2021) Heterogeneous ketonic decarboxylation of dodecanoic acid: studying reaction parameters. RSC Advances, 11 (56). 35575 - 35584.

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Abstract

Ketonic decarboxylation has gained significant attention in recent years as a pathway to reduce the oxygen content within biomass-derived oils, and to produce sustainable ketones. The reaction is base catalysed, with MgO an economic, accessible and highly basic heterogeneous catalyst. Here we use MgO to catalyse the ketonic decarboxylation of dodecanoic acid to form 12-tricosanone at moderate temperatures (250 degrees C, 280 degrees C and 300 degrees C) with low catalyst loads of 1% (w/w), 3% (w/w) and 5% (w/w) with respect to the dodecanoic acid, with a reaction time of 1 hour under batch conditions. Three different particle sizes for the MgO were tested (50 nm, 100 nm and 44 mu m). Ketone yield was found to increase with increasing reaction temperature, reaching approximately 75% yield for all the samples tested. Temperature was found to be the main control on reaction yield, rather than surface area or particle size.

Item Type: Article
Additional Information: © 2021 The Authors. British Journal of Pharmacology published by John Wiley & Sons Ltd on behalf of The British Pharmacological Society.This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Subjects: R Medicine > RA Public aspects of medicine
R Medicine > RM Therapeutics. Pharmacology
R Medicine > RS Pharmacy and materia medica
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Depositing User: Symplectic
Date Deposited: 08 Dec 2021 10:35
Last Modified: 11 Feb 2022 11:49
URI: https://eprints.keele.ac.uk/id/eprint/10338

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