Mutepfa, AR, Hardy, JG and Adams, CF ORCID: https://orcid.org/0000-0002-7333-9908 (2022) Electroactive Scaffolds to Improve Neural Stem Cell Therapy for Spinal Cord Injury. Frontiers in Medical Technology, 4. 693438 - ?.

[img]
Preview
Text
fmedt-04-693438.pdf - Published Version
Available under License Creative Commons Attribution.

Download (2MB) | Preview

Abstract

Spinal cord injury (SCI) is a serious condition caused by damage to the spinal cord through trauma or disease, often with permanent debilitating effects. Globally, the prevalence of SCI is estimated between 40 to 80 cases per million people per year. Patients with SCI can experience devastating health and socioeconomic consequences from paralysis, which is a loss of motor, sensory and autonomic nerve function below the level of the injury that often accompanies SCI. SCI carries a high mortality and increased risk of premature death due to secondary complications. The health, social and economic consequences of SCI are significant, and therefore elucidation of the complex molecular processes that occur in SCI and development of novel effective treatments is critical. Despite advances in medicine for the SCI patient such as surgery and anaesthesiology, imaging, rehabilitation and drug discovery, there have been no definitive findings toward complete functional neurologic recovery. However, the advent of neural stem cell therapy and the engineering of functionalized biomaterials to facilitate cell transplantation and promote regeneration of damaged spinal cord tissue presents a potential avenue to advance SCI research. This review will explore this emerging field and identify new lines of research.

Item Type: Article
Additional Information: © 2022 Mutepfa, Hardy and Adams. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Uncontrolled Keywords: spinal cord injury, cell therapy, tissue engineering & regenerative medicine, electroactive, electrical stimulation
Subjects: Q Science > Q Science (General)
Q Science > QP Physiology
Divisions: Faculty of Natural Sciences > School of Life Sciences
Related URLs:
Depositing User: Symplectic
Date Deposited: 28 Mar 2022 14:11
Last Modified: 28 Mar 2022 14:11
URI: https://eprints.keele.ac.uk/id/eprint/10777

Actions (login required)

View Item View Item