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Munkuev, AA, Dyrkheeva, NS, Kornienko, TE, Ilina, ES, Ivankin, DI, Suslov, EV, Korchagina, DV, Gatilov, YV, Zakharenko, AL, Malakhova, AA, Reynisson, J ORCID: https://orcid.org/0000-0003-4174-9512, Volcho, KP, Salakhutdinov, NF and Lavrik, OI (2022) Adamantane-Monoterpenoid Conjugates Linked via Heterocyclic Linkers Enhance the Cytotoxic Effect of Topotecan. Molecules, 27 (11).

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Abstract

Inhibiting tyrosyl-DNA phosphodiesterase 1 (TDP1) is a promising strategy for increasing the effectiveness of existing antitumor therapy since it can remove the DNA lesions caused by anticancer drugs, which form covalent complexes with topoisomerase 1 (TOP1). Here, new adamantane-monoterpene conjugates with a 1,2,4-triazole or 1,3,4-thiadiazole linker core were synthesized, where (+)-and (-)-campholenic and (+)-camphor derivatives were used as monoterpene fragments. The campholenic derivatives 14a-14b and 15a-b showed activity against TDP1 at a low micromolar range with IC50 ~5-6 μM, whereas camphor-containing compounds 16 and 17 were ineffective. Surprisingly, all the compounds synthesized demonstrated a clear synergy with topotecan, a TOP1 poison, regardless of their ability to inhibit TDP1. These findings imply that different pathways of enhancing topotecan toxicity other than the inhibition of TDP1 can be realized.

Item Type:	Article
Additional Information:	This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
Uncontrolled Keywords:	tyrosyl-DNA phosphodiesterase 1; adamantane; monoterpene; TDP1 inhibitors; 1,2,4-triazole; 1,3,4-thiadiazole; synergy
Subjects:	Q Science > Q Science (General)
Divisions:	Faculty of Medicine and Health Sciences > School of Pharmacy and Bioengineering
Related URLs:	Author
Depositing User:	Symplectic
Date Deposited:	15 Jul 2022 10:54
Last Modified:	21 Jul 2022 14:21
URI:	https://eprints.keele.ac.uk/id/eprint/11085

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