Keele Research Repository

Raisi-Estabragh, Z, Kobo, O, Elbadawi, A, Velagapudi, P, Sharma, G, Bullock-Palmer, RP, Petersen, SE, Mehta, LS, Ullah, W, Roguin, A, Sun, LY and Mamas, MA ORCID: https://orcid.org/0000-0001-9241-8890 (2022) Differential patterns and outcomes of over 20.6 million cardiovascular emergency department encounters for men and women in the USA. Journal of the American Heart Association. (In Press)

Text EDCVD_Manuscript_JAHAR4_July20_CLEAN.docx - Accepted Version Restricted to Repository staff only Download (521kB)

Abstract

Background: We describe sex-differential disease patterns and outcomes of over 20.6 million cardiovascular emergency department (ED) encounters in the USA. Methods and Results: We analysed primary cardiovascular encounters from the Nationwide Emergency Department Sample between 2016-2018. We grouped cardiovascular diagnoses into 15 disease categories. The sample included 48.7% women; median age was 67 [54,78] years. Men had greater overall baseline co-morbidity burden; however, women had higher rates of obesity, hypertension, and cerebrovascular disease. For women, the most common ED encounters were essential hypertension (16.0%), hypertensive heart or kidney disease (14.1%), and atrial fibrillation (AF)/flutter (10.2%). For men, the most common encounters were hypertensive heart or kidney disease (14.7%), essential hypertension (10.8%), and acute myocardial infarction (AMI, 10.7%). Women were more likely to present with essential hypertension, hypertensive crisis, AF/flutter, supraventricular tachycardia, pulmonary embolism, or ischaemic stroke. Men were more likely to present with AMI or cardiac arrest. In logistic regression models adjusted for baseline covariates, compared to men, women with intracranial haemorrhage had higher risk of hospitalisation and death. Women with ischaemic stroke had higher risk of hospitalisation and death in ED. Women presenting with pulmonary embolism or deep vein thrombosis were less likely to be hospitalised. Women with aortic aneurysm/dissection had higher odds of hospitalisation and death. Men were more likely to die following presentations with hypertensive heart or kidney disease, AF/flutter, AMI, or cardiac arrest. Conclusions: In this large nationally representative sample of cardiovascular ED presentations, we demonstrate significant sex differences in disease distribution, hospitalisation, and death.

Item Type:	Article
Additional Information:	The final version of this article and all relevant information related to it, including copyrights, can be found on the publisher website upon publication.
Subjects:	R Medicine > R Medicine (General) R Medicine > RC Internal medicine > RC666 Diseases of the circulatory (Cardiovascular) system
Divisions:	Faculty of Medicine and Health Sciences > School of Medicine
Depositing User:	Symplectic
Date Deposited:	26 Jul 2022 12:30
Last Modified:	26 Jul 2022 12:30
URI:	https://eprints.keele.ac.uk/id/eprint/11150

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