Increased circulating Dickkopf-1 in Paget's disease of bone
Abstract
Dickkopf-1 (Dkk-1) is a secreted inhibitor of Wnt signaling which in adults regulates bone turnover. Dkk-1 over-production is implicated in osteolytic disease where it inhibits bone formation and stimulates bone breakdown. Recently it was reported that osteoblastic cells from Paget's disease of bone (PDB) over-expressed Dkk-1.
Objective
To see if increased Dkk-1 was detected in serum from patients with PDB.
Results
Dkk-1 and total serum alkaline phosphatase activity (tsAP) were significantly elevated in sera from PDB patients. Patients with polyostotic PDB had significantly higher levels of tsAP but not Dkk-1, than monostotic patients. TsAP but not Dkk-1, was significantly lower in sera from bisphosphonate treated versus untreated PDB patients. Dkk-1 and tsAP were not significantly correlated.
Conclusions
Dkk-1 may be a useful biomarker of PDB and we speculate that Dkk-1 may play a central role in the etiology of PDB.
Acceptance Date | Apr 7, 2009 |
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Publication Date | Apr 21, 2009 |
Journal | Clinical Biochemistry |
Print ISSN | 0009-9120 |
Publisher | Elsevier |
Pages | 965-969 |
DOI | https://doi.org/10.1016/j.clinbiochem.2009.04.007 |
Keywords | Dickkopf-1, Serum, Paget's disease of bone, Alkaline phosphatase, Wnt, Inhibitor |
Publisher URL | https://doi.org/10.1016/j.clinbiochem.2009.04.007 |
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