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Barnett, L, Jordan, KP ORCID: https://orcid.org/0000-0003-4748-5335, Edwards, JJ and van der Windt, DA (2017) Does metformin protect against osteoarthritis? An electronic health record cohort study. Primary Health Care Research and Development, 18 (6). pp. 623-628.

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Abstract

Background
Obesity is a major risk factor for osteoarthritis (OA) whilst there is some evidence that diabetes also increases risk. Metformin is a common oral treatment for those with diabetes.

Objective
The aim is to investigate whether metformin reduces the risk of OA.

Methods
This was a cohort study set within the Consultations in Primary Care Archive, with 3217 patients with type 2 diabetes. Patients at 13 general practices with recorded type 2 diabetes in the baseline period (2002–2003) and no prior record of OA were identified. Exposure was a prescription for metformin. Outcome was an OA record during follow up. Cox proportional hazard models with Gamma frailty term were fitted: adjusted for age, gender, deprivation, and comorbidity.

Results
There was no association between prescribed metformin treatment at baseline and OA (adjusted HR: 1.02, 95% CI: 0.91, 1.15). A similar non- significant association was found when allowing exposure status of prescription of metformin to vary over time.

Item Type:	Article
Additional Information:	This is the accepted author manuscript (AAM). The final published version (version of record) is available online via Cambridge University Press at http://doi.org/10.1017/S1463423617000287 - please refer to any applicable terms of use of the publisher.
Uncontrolled Keywords:	cohort, osteoarthritis, survival analysis
Subjects:	R Medicine > R Medicine (General) R Medicine > RA Public aspects of medicine R Medicine > RC Internal medicine > RC925 Diseases of the musculoskeletal system
Divisions:	Faculty of Medicine and Health Sciences > Primary Care Health Sciences
Depositing User:	Symplectic
Date Deposited:	22 May 2017 11:02
Last Modified:	08 Apr 2021 10:35
URI:	https://eprints.keele.ac.uk/id/eprint/3488

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