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Fang, L, Trigiante, G, Kousseff, CJ, Crespo-Otero, R, Philpott, MP and Watkinson, M ORCID: https://orcid.org/0000-0003-1877-5667
(2018)
Biotin-tagged fluorescent sensor to visualize 'mobile' Zn2+ in cancer cells.
Chemical Communications (69).
pp. 9619-9266.
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Text
Acceptedmanuscript.docx - Accepted Version Available under License Creative Commons Attribution Non-commercial. Download (1MB) |
Official URL: http://doi.org/10.1039/c8cc05425h
Abstract
A cancer cell-targeting fluorescent sensor has been developed to image mobile Zn2+ by introducing a biotin group. It shows a highly selective response to Zn2+ in vitro, no toxicity in cellulo and images 'mobile' Zn2+ specifically in cancer cells. We believe this probe has the potential to help improve our understanding of the role of Zn2+ in the processes of cancer initiation and development.
Item Type: | Article |
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Additional Information: | This is the accepted author manuscript (AAM). The final published version (version of record) is available online via Royal Society of Chemistry at http://doi.org/10.1039/c8cc05425h - please refer to any applicable terms of use of the publisher. |
Subjects: | Q Science > QD Chemistry > QD415 Biochemistry R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) |
Divisions: | Faculty of Natural Sciences > School of Chemical and Physical Sciences |
Related URLs: | |
Depositing User: | Symplectic |
Date Deposited: | 22 Aug 2018 08:31 |
Last Modified: | 10 Aug 2019 01:30 |
URI: | https://eprints.keele.ac.uk/id/eprint/5232 |
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