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Varnava, KG, Reynisson, J ORCID: https://orcid.org/0000-0003-4174-9512, Raghothama, S and Sarojini, V (2018) Synthesis, antibacterial, and antibiofilm potential of human autophagy 16 polypeptide and analogues. Peptide Science, 110 (4). e24076.

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Abstract

This work demonstrates that the human autophagy 16 polypeptide (Atg16) has antibacterial and antibiofilm potential, perturbs both Gram positive and negative bacterial membranes and subsequently also produces ROS in compromised bacteria. Engineered Atg 16 analogues containing 1‐ and 2‐naphthyl alanines showed significant enhancement of antibacterial activity and eradicated biofilms while also possessing negligible hemolysis of mouse erythrocytes. This new family of antibacterial peptides are promising candidates in the fight against bacterial biofilms, responsible for several thousand deaths annually which are predicted to rise into the millions.

Item Type:	Article
Uncontrolled Keywords:	antimicrobial peptide, biofilm, membrane lysis, scanning electron microscopy, transmission electron microscopy
Subjects:	Q Science > QD Chemistry R Medicine > RM Therapeutics. Pharmacology
Divisions:	Faculty of Medicine and Health Sciences > School of Pharmacy
Related URLs:	Author
Depositing User:	Symplectic
Date Deposited:	28 Feb 2019 12:31
Last Modified:	08 Mar 2019 14:55
URI:	https://eprints.keele.ac.uk/id/eprint/5946

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