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Synthesis of benz- and cyclohepta-pyridines

Jones, Ronald K

Synthesis of benz- and cyclohepta-pyridines Thumbnail


Authors

Ronald K Jones



Abstract

The methods of synthesis of benzocyclohepteneones are reviewed.
A sequential Claisen - Dieckmann condensation has been used to prepare di-alkyl 5,9-dihydroxy-7H-cyclohepta-[b]-and-[c]-pyridine-6,8-dicarboxylates.
These have been converted to the cyclopropaquinoline and cyclopropaisoquinoline-diones.
A review of some of the methods of preparing quinolines and isoquinolines is included.
The sequential condensation was adapted to prepare diethyl 5,8-dihydroxyquinoline-6,7-dicarboxylate and diethyl 5,8-dihydroxyisoquinoline-6,7-dicarboxylate which were oxidised to the corresponding quinones.
The quinoline-5,8-dione acted as a dienophile with cyclopentadiene.
Diels Alder adducts of the pyrido-[2,3-d]-and[3 ,4-d] - pyridazine-1,4-diones have been prepared.
9H-cyclohepta-[b] -pyridine-9-one has been synthesised.
Ynamine chemistry is reviewed. The reaction of ynamines with carboxylic acids has been studied. An attempt was made to perform a photochemical cycloaddition using an ynamine.

Publicly Available Date Mar 29, 2024

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