Dicken, AJ, Evans, JPO, Rogers, KD, Stone, N, Greenwood, CE ORCID: https://orcid.org/0000-0003-1332-3864, Godber, SX, Prokopiou, D, Clement, JG, Lyburn, ID, Martin, RM and Zioupos, P (2015) X-ray diffraction from bone employing annular and semi-annular beams. Physics in Medicine and Biology, 60 (15). 5803 - 5812.

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Abstract

There is a compelling need for accurate, low cost diagnostics to identify osteotissues that are associated with a high risk of fracture within an individual. To satisfy this requirement the quantification of bone characteristics such as ‘bone quality’ need to exceed that provided currently by densitometry. Bone mineral chemistry and microstructure can be determined from coherent x-ray scatter signatures of bone specimens. Therefore, if these signatures can be measured, in vivo, to an appropriate accuracy it should be possible by extending terms within a fracture risk model to improve fracture risk prediction.
In this preliminary study we present an examination of a new x-ray diffraction technique that employs hollow annular and semi-annular beams to measure aspects of ‘bone quality’. We present diffractograms obtained with our approach from ex vivo bone specimens at Mo Kα and W Kα energies.
Primary data is parameterized to provide estimates of bone characteristics and to indicate the precision with which these can be determined.

Item Type: Article
Additional Information: Content from this work may be used under the terms of the Creative Commons Attribution 3.0 licence. Any further distribution of this work must maintain attribution to the author(s) and the title of the work, journal citation and DOI.
Uncontrolled Keywords: x-ray diffraction, diagnostics, osteoporosis, annular beam
Subjects: R Medicine > R Medicine (General)
R Medicine > RC Internal medicine > RC925 Diseases of the musculoskeletal system
Divisions: Faculty of Medicine and Health Sciences > Primary Care Health Sciences
Depositing User: Symplectic
Date Deposited: 17 Apr 2019 12:14
Last Modified: 18 Mar 2021 16:30
URI: https://eprints.keele.ac.uk/id/eprint/6201

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