Watkinson
Aggregation-Induced Emission (AIE) Fluorophore Exhibits a Highly Ratiometric Fluorescent Response to Zn2+ in vitro and in Human Liver Cancer Cells
Watkinson
Authors
Abstract
Two novel organic fluorophores, containing bis-naphthylamide and quinoline motifs, have been designed and synthesized. One of the fluorophores contains an isobutylene unit and exhibits a significant aggregation-induced emission (AIE) and a remarkable highly selective ratiometric fluorescence response towards Zn2+ in solution as well as in human liver cancer cells. The AIE behavior of this fluorophore was fully verified by fluorescence and UV/Vis spectroscopy, quantum yield calculations, and single-crystal X-ray diffraction, which revealed an intricate crystal packing system. Conversely, a fluorophore that lacks the isobutylene moiety did not exhibit any significant fluorescent properties as a result of its more flexible molecular structure that presumably allows free intramolecular rotational processes to occur.
Acceptance Date | Jun 14, 2017 |
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Publication Date | Aug 1, 2017 |
Journal | Chemistry: A European Journal |
Print ISSN | 0947-6539 |
Publisher | Wiley |
Pages | 13067 - 13075 |
DOI | https://doi.org/10.1002/chem.201701948 |
Keywords | aggregation-induced emission, bioimaging, flurophores, sensors, zinc |
Publisher URL | https://doi.org/10.1002/chem.201701948 |
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