Borovac, JA, Kwok, CS ORCID: https://orcid.org/0000-0001-7047-1586, Iliescu, C, Lee, HJ, Kim, PY, Palaskas, NL, Zaman, A, Butler, R, Lopez-Mattei, JC and Mamas, MA ORCID: https://orcid.org/0000-0001-9241-8890 (2019) Percutaneous Coronary Intervention and Outcomes in Patients with Lymphoma in the United States (Nationwide Inpatient Sample [NIS] analysis). The American Journal of Cardiology, 124 (8). pp. 1190-1197.

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Abstract

Characteristics and outcomes of patients with lymphoma undergoing PCI are unknown. Therefore, we analyzed clinical characteristics and outcomes in patients that underwent percutaneous coronary intervention (PCI) and had a concomitant diagnosis of Hodgkin’s (HL) or non-Hodgkin’s (NHL) lymphoma. We analyzed patients with and without lymphoma diagnosis from the Nationwide Inpatient Sample in the US who underwent PCI procedure during 2004-2014. Multivariable regression analysis was performed to examine the association between lymphoma diagnosis and clinical outcomes post-PCI including shortterm complications and in-hospital mortality. A total of 7,119,539 PCI procedures were included in the analysis and 18,052 patients had a diagnosis of lymphoma (0.25%). These patients were likely to experience in-hospital mortality (OR 1.39, 95%CI 1.25-1.54), stroke or transient ischemic attack (TIA) (OR 1.75, 95%CI 1.61-1.90), and any in-hospital complication (OR 1.31, 95%CI 1.25-1.37), following PCI. In the lymphoma subtypeanalysis, diagnosis of HL was associated with an increased odds of in-hospital death (OR 1.40, 95% CI 1.24-1.56), any in-hospital complication (OR 1.31, 95% CI 1.25-1.38), bleeding complications (OR 1.12 95% CI 1.05-1.20) and vascular complications (OR 1.13 95%CI 1.06-1.20) while these odds were not significantly associated with NHL diagnosis. Finally, both types of lymphoma were associated with an increased odds of stroke/TIA following PCI (OR 1.82, 95% CI 1.67-1.99 and OR 1.31, 95% CI 1.05-1.63, respectively). In conclusion, while the prevalence of lymphoma in the observed PCI cohort was low, a diagnosis of lymphoma was associated with an adverse prognosis following PCI, primarily in patients with the HL diagnosis.

Item Type: Article
Additional Information: The final published version of this accepted manuscript is available online at https://doi.org/10.1016/j.amjcard.2019.07.015
Uncontrolled Keywords: Lymphoma; Coronary Artery Disease; Complications; Mortality
Subjects: R Medicine > R Medicine (General)
Divisions: Faculty of Medicine and Health Sciences > Primary Care Health Sciences
Depositing User: Symplectic
Date Deposited: 29 Jul 2019 08:14
Last Modified: 24 Jul 2020 01:30
URI: https://eprints.keele.ac.uk/id/eprint/6598

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