Keele Research Repository

Chen, WMY, Subesinghe, S, Muller, SN ORCID: https://orcid.org/0000-0001-6645-5751, Hider, SL, Mallen, CD ORCID: https://orcid.org/0000-0002-2677-1028 and Scott, IC (2019) The association between gravidity, parity and the risk of developing rheumatoid arthritis: A systematic review and meta-analysis. Seminars in Arthritis and Rheumatism, 50 (2). pp. 252-260.

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Abstract

OBJECTIVE: To establish if gravidity and parity associate with the development of rheumatoid arthritis (RA), and to establish if this effect is influenced by the time elapsed since pregnancy/childbirth, the number of pregnancies/childbirths, and serological status, through systematically reviewing the literature and undertaking a meta-analysis. METHODS: We searched Medline/EMBASE (from 1946 to 2018) using the terms "rheumatoid arthritis.mp" or "arthritis, rheumatoid/" and "pregnancy.mp" or "pregnancy/" or "parity.mp" or "parity/" or "gravidity.mp" or "gravidity/" (observational study filter applied). Case-control/cohort studies that examined the relationship between parity/gravidity and the risk of RA in women were included. Studies reporting effect size data for RA in ever vs. never parous/gravid women as ORs/RRs with 95% confidence intervals were included in a meta-analysis. Other relationships (i.e. risk by pregnancy/childbirth numbers) were analysed descriptively. RESULTS: Twenty studies (from 626 articles) met our inclusion criteria, comprising 14 case-control (4799 cases; 11,941 controls) and 6 cohort studies (8575 cases; 2,368,439 individuals). No significant association was observed in the meta-analysis of studies reporting the risk of RA in ever vs. never parous women (OR 0.91; 95% CI 0.80-1.04) and ever vs. never gravid women (OR 0.86; 95% CI 0.46-1.62). No consistent evidence of a relationship between the number of pregnancies/childbirths and RA risk was seen. No significant association was observed between being pregnant, or in the immediate post-partum period, and the risk of developing RA. CONCLUSION: Our systematic review does not support the concept that gravidity and parity are associated with the risk of RA development.

Item Type:	Article
Additional Information:	The final version of this accepted manuscript is available online at https://www.sciencedirect.com/science/article/pii/S0049017219302471?via%3Dihub
Uncontrolled Keywords:	Arthritis; Rheumatoid; Parity; Gravidity; Meta-Analysis
Subjects:	R Medicine > R Medicine (General) R Medicine > RA Public aspects of medicine R Medicine > RC Internal medicine > RC925 Diseases of the musculoskeletal system
Divisions:	Faculty of Medicine and Health Sciences > School of Primary, Community and Social Care
Related URLs:	Author
Depositing User:	Symplectic
Date Deposited:	10 Oct 2019 14:36
Last Modified:	11 Sep 2020 01:30
URI:	https://eprints.keele.ac.uk/id/eprint/7010

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