N. Ditchfield
Unwarranted use of intravenous aminoglycosides at UK paediatric cystic fibrosis centres
Ditchfield, N.; Carroll, W.D.; Gilchrist, F.J.
Abstract
Highlights
IV aminoglycosides are frequently used to treat infective exacerbations in CF due to efficacy against PA.
The side effects of aminoglycosides include nephrotoxicity, ototoxicity and vestibulotoxicity.
More than one third of UK CF centres use tobramycin to treat pulmonary exacerbations in children who have never isolated PA.
More than one half of UK CF centres use tobramycin to treat pulmonary exacerbations in children free of PA for >12?months.
IV aminoglycosides should be reserved for infective exacerbations in which PA is confirmed or strongly suspected.
Acceptance Date | Sep 5, 2019 |
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Publication Date | Sep 12, 2019 |
Publicly Available Date | Mar 28, 2024 |
Journal | Journal of Cystic Fibrosis |
Print ISSN | 1569-1993 |
Publisher | Elsevier |
DOI | https://doi.org/10.1016/j.jcf.2019.09.004 |
Keywords | Acute kidney injury, Aminoglycosides, Chronic kidney disease, Cystic fibrosis, Pseudomonas aeruginosa |
Publisher URL | http://www.sciencedirect.com/science/article/pii/S1569199319308884 |
Files
Ditchfield JCF June 2019 Manuscript 2.docx
(100 Kb)
Document
Publisher Licence URL
https://creativecommons.org/licenses/by-nc-nd/4.0/
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