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Unwarranted use of intravenous aminoglycosides at UK paediatric cystic fibrosis centres

Ditchfield, N.; Carroll, W.D.; Gilchrist, F.J.

Authors

N. Ditchfield

W.D. Carroll



Abstract

Highlights

IV aminoglycosides are frequently used to treat infective exacerbations in CF due to efficacy against PA.

The side effects of aminoglycosides include nephrotoxicity, ototoxicity and vestibulotoxicity.

More than one third of UK CF centres use tobramycin to treat pulmonary exacerbations in children who have never isolated PA.

More than one half of UK CF centres use tobramycin to treat pulmonary exacerbations in children free of PA for >12?months.

IV aminoglycosides should be reserved for infective exacerbations in which PA is confirmed or strongly suspected.

Acceptance Date Sep 5, 2019
Publication Date Sep 12, 2019
Publicly Available Date Mar 28, 2024
Journal Journal of Cystic Fibrosis
Print ISSN 1569-1993
Publisher Elsevier
DOI https://doi.org/10.1016/j.jcf.2019.09.004
Keywords Acute kidney injury, Aminoglycosides, Chronic kidney disease, Cystic fibrosis, Pseudomonas aeruginosa
Publisher URL http://www.sciencedirect.com/science/article/pii/S1569199319308884