Shang, J, Yu, D ORCID: https://orcid.org/0000-0002-8449-7725, Cai, Y, Wang, Z, Zhao, B, Zhao, Z and Simmons, D (2019) The triglyceride glucose index can predict newly diagnosed biopsy-proven diabetic nephropathy in type 2 diabetes: A nested case control study. Medicine, 98 (46). e17995.

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Abstract

Insulin resistance is usually a key factor in the development of type 2 diabetes. The triglyceride glucose (TyG) index is a marker of insulin resistance which is also implicated in the risk of nephropathy among people with type 2 diabetes. This study aimed to examine associations and potential thresholds between TyG index and the risk of newly diagnosed biopsy-proven diabetic nephropathy in people with type 2 diabetes. A nested case–control study incorporating 950 incident biopsy-proven diabetic nephropathy cases and age, gender matched 4750 patients with treated type 2 diabetes as controls selected by risk-set sampling method was implemented. The dose–response association between TyG index with subsequent risk of newly diagnosed biopsy-proven diabetic nephropathy after adjustment for age, gender, blood pressure, and other major cardiovascular risk factors were examined by conditional logistic regression model. A non-linear relationship was identified between TyG index and the risk of newly diagnosed biopsy-proven diabetic nephropathy with a potential threshold of TyG at 9.05–9.09. Similar relationships with the same threshold were also found in the analyses by fasting glucose and triglyceride levels. TyG index might be a prognostic factor in predicting newly development of biopsy-proven diabetic nephropathy among patients with treated type 2 diabetes. In people with type 2 diabetes, TyG index above 9.05–9.09 could be a prognostic threshold to identify individuals at high risk of diabetic nephropathy. Further replication studies are warranted.

Item Type: Article
Additional Information: This is the final published version of the article (version of record). It first appeared online via Wolters Kluwer at http://doi.org/10.1097/MD.0000000000017995 - please refer to any applicable terms of use of the publisher.
Uncontrolled Keywords: diabetes, diabetic retinopathy, insulin resistance, prognosis, TyG index
Subjects: R Medicine > RC Internal medicine > RC660 Diabetes
R Medicine > RC Internal medicine > RC902 Nephrology
Divisions: Faculty of Medicine and Health Sciences > Primary Care Health Sciences
Related URLs:
Depositing User: Symplectic
Date Deposited: 22 Nov 2019 14:36
Last Modified: 18 Dec 2019 11:09
URI: https://eprints.keele.ac.uk/id/eprint/7282

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