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Cardiac Progenitor Cells from Stem Cells: Learning from Genetics and Biomaterials

Barreto, Sara; Hamel, Leonie; Schiatti, Teresa; Yang, Ying; George, Vinoj

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Authors

Sara Barreto

Leonie Hamel

Teresa Schiatti



Abstract

Cardiac Progenitor Cells (CPCs) show great potential as a cell resource for restoring cardiac function in patients affected by heart disease or heart failure. CPCs are proliferative and committed to cardiac fate, capable of generating cells of all the cardiac lineages. These cells offer a significant shift in paradigm over the use of human induced pluripotent stem cell (iPSC)-derived cardiomyocytes owing to the latter's inability to recapitulate mature features of a native myocardium, limiting their translational applications. The iPSCs and direct reprogramming of somatic cells have been attempted to produce CPCs and, in this process, a variety of chemical and/or genetic factors have been evaluated for their ability to generate, expand, and maintain CPCs in vitro. However, the precise stoichiometry and spatiotemporal activity of these factors and the genetic interplay during embryonic CPC development remain challenging to reproduce in culture, in terms of efficiency, numbers, and translational potential. Recent advances in biomaterials to mimic the native cardiac microenvironment have shown promise to influence CPC regenerative functions, while being capable of integrating with host tissue. This review highlights recent developments and limitations in the generation and use of CPCs from stem cells, and the trends that influence the direction of research to promote better application of CPCs.

Journal Article Type Article
Acceptance Date Nov 21, 2019
Publication Date Nov 28, 2019
Publicly Available Date Mar 29, 2024
Journal Cells
Publisher MDPI
Peer Reviewed Peer Reviewed
Volume 8
Issue 12
DOI https://doi.org/10.3390/cells8121536
Keywords biomaterials, cardiac progenitor cells, cardiac tissue engineering, direct reprogramming, genetic engineering, induced pluripotent stem cells, transdifferentiation
Publisher URL https://doi.org/10.3390/cells8121536

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