Allotey, J, Marlin, N, Mol, BW, Von Dadelszen, P, Ganzevoort, W, Akkermans, J, Ahmed, A, Daniels, J, Deeks, J, Ismail, K, Barnard, AM, Dodds, J, Kerry, S, Moons, C, Khan, KS, Riley, RD ORCID: and Thangaratinam, S (2017) Development and validation of prediction models for risk of adverse outcomes in women with early-onset pre-eclampsia: protocol of the prospective cohort PREP study. Diagnostic and Prognostic Research, 1 (6). 6 - ?.

Development and validation of prediction models for risk of adverse outcomes in women with early-onset pre-eclampsia protoco.pdf - Accepted Version
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Background: Early-onset pre-eclampsia with raised blood pressure and protein in the urine before 34 weeks' gestation is one of the leading causes of maternal deaths in the UK. The benefits to the child from prolonging the pregnancy need to be balanced against the risk of maternal deterioration. Accurate prediction models of risks are needed to plan management. Methods: We aim to undertake a multicentre prospective cohort study (Prediction of Risks in Early onset Pre-eclampsia (PREP)) to develop clinical prediction models in women with early-onset pre-eclampsia, for risk of adverse maternal outcomes by 48 h and by discharge. We will externally validate the models in two independent cohorts with 634 and 216 women. In the secondary analyses, we will assess risk of adverse fetal and neonatal outcomes at birth and by discharge. Discussion: The PREP study will quantify the risk of maternal complications at various time points and provide individualised estimates of overall risk in women with early-onset pre-eclampsia to plan the management. Trial registration: ISRCTN registry, ISRCTN40384046.

Item Type: Article
Additional Information: Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.
Uncontrolled Keywords: pre-eclampsia, PREP study, early-onset.
Subjects: H Social Sciences > H Social Sciences (General)
Q Science > Q Science (General)
R Medicine > R Medicine (General)
Divisions: Faculty of Medicine and Health Sciences > School of Primary, Community and Social Care
Related URLs:
Depositing User: Symplectic
Date Deposited: 23 Jan 2020 16:08
Last Modified: 23 Jan 2020 16:08

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