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Kulshrestha, R, Kuiper, JH 
ORCID: https://orcid.org/0000-0002-7023-4078, Masri, WE, Chowdhury, JR, Kaur, S, Kumar, N, Lalam, R and Osman, AE
(2020)
Scoliosis in paediatric onset spinal cord injuries.
Spinal Cord.
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Abstract
STUDY DESIGN: This is a retrospective longitudinal review. OBJECTIVE: The purpose of this review was to identify predictors of developing clinical scoliosis and compare between traumatic and neurological aetiologies of SCI. SETTING: This study was conducted at the Midland Centre of SCI. METHOD: Case notes of all patients injured at an age up to 18 years and admitted between 1971 and 2013 were reviewed. RESULTS: Sixty-nine individuals were identified, of which seven were excluded: three with pre-existing scoliosis and four with spina bifida. The remaining 62 (44 males, 18 females) had a median age at injury of 17 years (inter quartile range 13-17). Of these, 51 (82%) had traumatic and 11 (18%) had neurological injury. Most (42/51; 82%) of the children who had a traumatic injury were older than 13 years. The risk of developing scoliosis was lower for older patients (RR 0.68 per year, 95% CI 0.52-0.83) or following a traumatic injury (RR 0.36, 95% CI 0.20-0.66). A multivariable analysis based on age and trauma showed that only older age decreased the risk. A robust Receiver Operator Curve analysis suggested 14.6 years as the optimal threshold to predict development of scoliosis within 10 years (Area Under the Curve; AUC 0.83 (95% CI 0.73-0.93), sensitivity 70% (95% CI 50-89%), specificity 89% (95% CI 74-100%). CONCLUSION: Our results suggest that age below 14.6 years was a predictor for scoliosis. Once adjustment is made for age, the incidence of scoliosis does not differ between traumatic and neurological aetiologies of paediatric SCI injury.
| Item Type: | Article |
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| Additional Information: | The final accepted article and all relevant information can be found at; https://www.nature.com/articles/s41393-020-0418-6 |
| Uncontrolled Keywords: | scoliosis, paediatric, spinal cord injuries. |
| Subjects: | Q Science > Q Science (General) Q Science > QM Human anatomy R Medicine > R Medicine (General) R Medicine > R Medicine (General) > R735 Medical education. Medical schools. Research |
| Divisions: | Faculty of Medicine and Health Sciences > School of Pharmacy and Bioengineering |
| Related URLs: | |
| Depositing User: | Symplectic |
| Date Deposited: | 09 Mar 2020 11:36 |
| Last Modified: | 20 Jul 2020 01:30 |
| URI: | https://eprints.keele.ac.uk/id/eprint/7765 |
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