Thomas, MJ ORCID: https://orcid.org/0000-0002-4951-9925 and Neogi, T (2020) Flare-ups of osteoarthritis: what do they mean in the short-term and the long-term? Osteoarthritis and Cartilage.

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Abstract

Symptoms of osteoarthritis (OA) evolve over years with variable rate and course. While studies have focused on understanding long-term trajectories of OA [e.g., 1 ], how these relate to shorter-term fluctuations in symptoms is not well-understood. Yet for many people, the lived experience of OA is recurrent fluctuations in episodic pain of varying frequency, intensity and duration; it is these episodes of increased pain and associated disability that often drive primary healthcare consultation. Historically, the term ‘exacerbation’ and ‘flare-up’ have been used interchangeably to describe sudden-onset episodes of increased pain; the term ‘flare-up’ has been adopted herein 2 . Patients describe flare-ups as being unpredictable and distressing, particularly in advanced stages 3 . Because of the recognized importance of flare-ups to the patient experience, there have been efforts to develop diagnostic criteria and consensus definition for OA flare-ups 4 , 5 , though a specific definition has not yet been widely accepted or validated. It is also important to differentiate between flare-ups and ‘complications’ that may result in symptoms (e.g., subchondral insufficiency micro-fracture), as treatment strategies will differ.

Item Type: Article
Additional Information: The final version of this accepted manuscript can be accessed via the publisher at https://www.sciencedirect.com/science/article/abs/pii/S1063458420300303
Uncontrolled Keywords: Osteoarthritis; Flare-up; Pain
Subjects: R Medicine > R Medicine (General)
R Medicine > RA Public aspects of medicine
R Medicine > RC Internal medicine > RC925 Diseases of the musculoskeletal system
Divisions: Faculty of Medicine and Health Sciences > Primary Care Health Sciences
Related URLs:
Depositing User: Symplectic
Date Deposited: 14 Apr 2020 09:06
Last Modified: 29 Jul 2020 09:57
URI: https://eprints.keele.ac.uk/id/eprint/7874

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