Keele Research Repository

Mohamed, MO ORCID: https://orcid.org/0000-0002-9678-5222, Polad, J, Hildick-Smith, D, Bizeau, O, Baisebenov, RK, Roffi, M, Iñiguez-Romo, A, Chevalier, B, von Birgelen, C, Roguin, A, Aminian, A, Angioi, M and Mamas, M ORCID: https://orcid.org/0000-0001-9241-8890 (2020) Impact of coronary lesion complexity in percutaneous coronary intervention: 1-year outcomes from the large, multicenter e-ULTIMASTER registry. EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, 16 (7). pp. 603-612.

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Abstract

Aims: The present study sought to examine the prevalence, clinical characteristics and 1-year outcomes of patients undergoing percutaneous coronary intervention (PCI) to complex lesions (multivessel PCI, ≥3 stents, ≥3 lesions, bifurcation with ≥2 stents, total stent length> 60mm or
chronic total occlusion (CTO)) in a prospective multicentre registry. Methods and Results: Using the e-Ultimaster multicentre registry, a post-hoc sub-group analysis was performed on 35,839 patients undergoing PCI, stratified by procedure complexity, and further by number and type of complex features. Overall, complex PCI patients (n=9,793,
27.3%) were older, more comorbid and were associated with an increased hazard ratio (HR) of composite endpoint at 1-year (target lesion failure (TLF): 1.41 [1.25; 1.59]), driven by increased hazard of cardiac death (1.28 [1.05; 1.55]), target vessel myocardial infarction (1.48 [1.18; 1.86]) and clinically driven target lesion revascularisation. The hazard of complications increased with rising number of complex features (3-6 vs. 1-2 vs. none) for all outcomes. All individual complex features were associated with an increased hazard of composite complications (except CTO) and definite/probable stent thrombosis. Conclusions: Overall, complex PCI is associated with an increased risk of mortality and complications at 1-year. The number and types of complex features have differing impacts on long-term outcomes.

Item Type:	Article
Additional Information:	The final version of this article and all relevant information regarding copyrights can be found at; https://eurointervention.pcronline.com/article/impact-of-coronary-lesion-complexity-in-percutaneous-coronary-intervention-one-year-outcomes-from-the-large-multicentre-e-ultimaster-registry
Uncontrolled Keywords:	Newer generation drug-eluting stent, clinical trials, Ultimaster sirolimuseluting stent; complex PCI; coronary interventions
Subjects:	Q Science > Q Science (General) R Medicine > RC Internal medicine > RC346 Neurology. Diseases of the nervous system, including speech disorders R Medicine > RD Surgery > RD32 Operative surgery. Technique of surgical operations
Divisions:	Faculty of Medicine and Health Sciences > School of Primary, Community and Social Care
Depositing User:	Symplectic
Date Deposited:	19 May 2020 14:45
Last Modified:	25 Jun 2021 01:30
URI:	https://eprints.keele.ac.uk/id/eprint/7946

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