Lavorini, F, Barreto, C, van Boven, JFM, Carroll, WD ORCID: https://orcid.org/0000-0003-2742-1836, Conway, J, Costello, RW, Hellqvist, B, Dekhuijzen, RPN, Holmes, S, Levy, M, Molimard, M, Roche, N, Román-Rodriguez, M, Schichilone, N, Scullion, J and Usmani, OS (2020) Spacers and Valved Holding Chambers—The Risk of Switching to Different Chambers. The Journal of Allergy and Clinical Immunology: In Practice, 8 (5). 1569 - 1573.

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Abstract

Spacers are pressurized metered-dose inhaler (pMDI) accessory devices developed to reduce problems of poor inhaler technique with pMDIs. Spacers that feature a 1-way inspiratory valve are termed valved holding chambers (VHCs); they act as aerosol reservoirs, allowing the user to actuate the pMDI device and then inhale the medication in a 2-step process that helps users overcome challenges in coordinating pMDI actuation with inhalation. Both spacers and VHCs have been shown to increase fine particle delivery to the lungs, decrease oropharyngeal deposition, and reduce corticosteroid-related side effects such as throat irritation, dysphonia, and oral candidiasis commonly seen with the use of pMDIs alone. Spacers and VHCs are not all the same, and also are not interchangeable: the performance may vary according to their size, shape, material of manufacture and propensity to become electrostatically charged, their mode of interface with the patient, and the presence or otherwise of valves and feedback devices. Thus, pairing of a pMDI plus a spacer or a VHC should be considered as a unique delivery system. In this Rostrum we discuss the risk potential for a patient getting switched to a spacer or VHC that delivers a reduced dose medication.

Item Type: Article
Additional Information: The final version of this article with all relevant information can be found at; https://www.sciencedirect.com/science/article/pii/S2213219820300337?via%3Dihub
Uncontrolled Keywords: SpacerValved holding chamberInhalers
Subjects: Q Science > Q Science (General)
R Medicine > R Medicine (General)
R Medicine > R Medicine (General) > R735 Medical education. Medical schools. Research
R Medicine > RC Internal medicine > RC705 Diseases of the respiratory system
Divisions: Faculty of Medicine and Health Sciences > School of Pharmacy and Bioengineering
Depositing User: Symplectic
Date Deposited: 28 May 2020 11:45
Last Modified: 28 May 2020 11:53
URI: https://eprints.keele.ac.uk/id/eprint/8049

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