Dr Michelle Marshall m.marshall@keele.ac.uk
Erosive osteoarthritis: a more severe form of radiographic hand osteoarthritis rather than a distinct entity?
Marshall, Michelle; Nicholls, Elaine; Kwok, Wing-Yee; Peat, George; Kloppenburg, Margreet; Van Der Windt, Danielle; Myers, Helen; Dziedzic, Krysia
Authors
Elaine Nicholls e.nicholls@keele.ac.uk
Wing-Yee Kwok
George Peat
Margreet Kloppenburg
Danielle Van Der Windt d.van.der.windt@keele.ac.uk
Helen Myers
Professor Krysia Dziedzic k.s.dziedzic@keele.ac.uk
Abstract
OBJECTIVES: To determine whether erosive osteoarthritis shares the same pattern of joint involvement and risk profile as increasing grades of non-erosive hand osteoarthritis. METHODS: Participants were from two population-based cohorts, aged =50 years, reporting hand symptoms in the previous month. Interphalangeal joints were assessed for erosive osteoarthritis (Verbruggen-Veys erosive or remodelled phase) and radiographic osteoarthritis (sliding cut-offs of K&L=2, K&L=3 and K&L=4). At the joint level, similarities in the frequency and pattern of erosive and non-erosive osteoarthritis were assessed by Spearman's rank correlation coefficients and generalised estimating equations. At the person level, individuals with erosive osteoarthritis were compared to those with non-erosive osteoarthritis using logistic regression, adjusted for age and gender (aOR), for the following exposures: family history, previous injury, overuse and metabolic factors (BMI, dyslipidaemia, hypertension, diabetes). RESULTS: In 1076 symptomatic participants the ranked frequency of involvement for erosive joints was comparable to joints with K&L=3 and K&L=4 (r>0.95). Patterns of joint involvement in erosive osteoarthritis were strongest for symmetry (aOR=6.5; 95% CI 3.0 to 14.1), followed by row (2.0; 0.8 to 5.0) and ray (0.3; 0.0 to 2.5), which was similar to joints with K&L=3 and K&L=4. Individuals with erosive osteoarthritis (n=80) had an increased risk of metabolic syndrome (2.7; 1.0 to 7.1), notably dyslipidaemia (4.7; 2.1 to 10.6) compared with non-erosive osteoarthritis classed K&L=3 (n=193). CONCLUSIONS: The similar frequency of radiographic joint involvement and patterning in erosive osteoarthritis and more severe non-erosive osteoarthritis is consistent with prevalent erosive osteoarthritis being a severe form of hand osteoarthritis rather than a distinct entity. Metabolic exposures, dyslipidaemia in particular, may be implicated in erosive osteoarthritis.
Journal Article Type | Article |
---|---|
Acceptance Date | Sep 20, 2013 |
Publication Date | Dec 4, 2014 |
Journal | Annals of the Rheumatic Diseases |
Print ISSN | 0003-4967 |
Publisher | BMJ Publishing Group |
Peer Reviewed | Peer Reviewed |
Volume | 74 |
Issue | 1 |
Pages | 136 - 141 |
DOI | https://doi.org/10.1136/annrheumdis-2013-203948 |
Keywords | Aged, Aged, 80 and over, Comorbidity, Dyslipidemias, Epidemiology, Female, Finger Joint, Hand Joints, Hand Osteoarthritis, Humans, Logistic Models, Male, Metabolic Syndrome, Middle Aged, Osteoarthritis, Radiography, Severity of Illness Index |
Publisher URL | https://ard.bmj.com/content/74/1/136 |
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